Human leukocyte antigens and drug hypersensitivity

被引：135

作者：

Chung, Wen-Hung

Hung, Shuen-Lu

Chen, Yuan-Tsong

机构：

[1] Acad Sinica, Inst Biomed Sci, Program Mol Med, Taiwan Int Grad Program, Taipei 11529, Taiwan

[2] Natl Yang Ming Univ, Sch Life Sci, Taipei 112, Taiwan

[3] Chang Gung Univ, Dept Dermatol, Taipei, Taiwan

[4] Chang Gung Univ, Coll Med, Taipei, Taiwan

[5] Natl Yang Ming Univ, Sch Med, Inst Pharmacol, Taipei 112, Taiwan

来源：

CURRENT OPINION IN ALLERGY AND CLINICAL IMMUNOLOGY | 2007年 / 7卷 / 04期

关键词：

drug hypersensitivity; human leukocyte antigen; immune reactions; pharmacogenetics;

D O I：

10.1097/ACI.0b013e3282370c5f

中图分类号：

R392 [医学免疫学];

学科分类号：

100102 ;

摘要：

The strong genetic association suggests a direct involvement of HLA in the pathogenesis of drug hypersensitivity when the HLA molecule presents an antigenic drug for T cell activation. The high sensitivity/ specificity of some markers provides a plausible basis for developing tests to identify individuals at risk for drug hypersensitivity. Application of HLA-13*1502 genotyping as a screening tool before prescribing carbamazepine could be a valuable tool in preventing carbamazepine-induced SJS/TEN in south-east Asian countries.

引用

页码：317 / 323

页数：7

共 49 条

[1] HLA-B locus in Caucasian patients with carbamazepine hypersensitivity [J].