C-10-fluorinated derivatives of dihydroartemisinin:: difluoromethylene ketones

被引：24

作者：

Chorki, F

Crousse, B

Bonnet-Delpon, D

Bégué, JP

Brigaud, T

Portella, C

机构：

[1] Fac Pharm Chatenay Malabry, CNRS, BIOCIS, F-92296 Chatenay Malabry, France

[2] CNRS, F-51687 Reims 2, France

[3] Fac Sci, F-51687 Reims 2, France

来源：

TETRAHEDRON LETTERS | 2001年 / 42卷 / 08期

关键词：

D O I：

10.1016/S0040-4039(00)02272-3

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Difluoroenoxysilanes, prepared from aromatic and heterocyclic ketones, reacted with dihydroartemisinin acetate in the presence of Lewis acid to provide in good to moderate yields the 10-substituted difluoromethylene ketones. The introduction of the difluoromethylketone moiety was accompanied by the epimerisation of C-9. Best results were obtained using SnCl4 as Lewis acid. (C) 2001 Published by Elsevier Science Ltd.

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页码：1487 / 1489

页数：3

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