Formation of stable nanocapsules from polymerizable phospholipids

被引：19

作者：

Lawson, GE ^{[1
]}

Lee, Y ^{[1
]}

Singh, A ^{[1
]}

机构：

[1] USN, Res Lab, Ctr Biomol Sci & Engn, Washington, DC 20375 USA

来源：

LANGMUIR | 2003年 / 19卷 / 16期

关键词：

D O I：

10.1021/la034434u

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

The formation of lipid-based hollow, spherical nanocapsules is reported. Polymerizable phospholipids equipped with divinylbenzoyl functionality in their headgroup region are synthesized to explore their polymerization behavior in vesicles. Polymerizable phospholipids alone or as mixtures with phosphatidylcholine produced vesicles as an aqueous dispersion and produced stable nanocapsules upon polymerization at room temperature. These structures survived lyophilization and a redispersion cycle and maintained their structural integrity in nonaqueous solvent. Vesicles were used for encapsulating enzymes in their hydrophilic cores.

引用

页码：6401 / 6407

页数：7

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