Cross-protection between distantly related spotted fever group rickettsiae

被引：22

作者：

Feng, HM ^{[1
]}

Walker, DH ^{[1
]}

机构：

[1] Univ Texas, Med Branch, Dept Pathol, Galveston, TX 77555 USA

来源：

VACCINE | 2003年 / 21卷 / 25-26期

关键词：

Rickettsia conorii; Rickettsia australis; mouse models; protective immunity; toxicity neutralization;

D O I：

10.1016/S0264-410X(03)00301-3

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 [免疫学];

摘要：

Two excellent C3H/HeN mouse models of spotted fever rickettsioses caused by the distantly related organisms, Rickettsia conorii and Rickettsia australis, were utilized to evaluate the possibility of the stimulation of broad cross-protective immunity. Sublethal infection stimulated complete immunity, that is absence of disease, after challenge with a dose of the heterologous Rickettsia that uniformly killed naive mice. In contrast, heterologous immune sera did not protect mice against a lethal dose (two LD50) of rickettsiae in the mouse toxicity neutralization assay, the standard method for evaluation of rickettsial vaccine potency. These observations suggest that development of a broadly protective vaccine against spotted fever group (SFG) rickettsiae is feasible, and the results indicate that mouse toxicity neutralization is an inappropriate method for evaluation of candidate vaccines. (C) 2003 Elsevier Science Ltd. All rights reserved.

引用

页码：3901 / 3905

页数：5

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