Inositol 1,3,4,5-tetrakisphosphate is essential for T lymphocyte development

被引：88

作者：

Pouillon, V

Hascakova-Bartova, R

Pajak, B

Adam, E

Bex, F

Dewaste, V

Van Lint, C

Leo, O

Erneux, C

Schurmans, S

机构：

[1] IRIBHN, IBMM, B-6041 Gosselies, Belgium

[2] IRIBHN, B-1070 Brussels, Belgium

[3] IBMM, Physiol Anim Lab, B-6041 Gosselies, Belgium

[4] IBMM, Chim Biol Lab, B-6041 Gosselies, Belgium

[5] CERIA, Microbiol Lab, B-1070 Brussels, Belgium

来源：

NATURE IMMUNOLOGY | 2003年 / 4卷 / 11期

关键词：

D O I：

10.1038/ni980

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Inositol 1,4,5-trisphosphate (Ins(1,4,5)P-3) is phosphorylated by Ins(1,4,5)P-3 3-kinase, generating inositol 1,3,4,5-tetrakisphosphate (Ins( 1,3,4,5) P-4). The physiological function of Ins( 1,3,4,5) P 4 is still unclear, but it has been reported to be a potential modulator of calcium mobilization. Disruption of the gene encoding the ubiquitously expressed Ins(1,4,5) P-3 3-kinase isoform B (Itpkb) in mice caused a severe T cell deficiency due to major alterations in thymocyte responsiveness and selection. However, we were unable to detect substantial defects in Ins(1,4,5) P-3 amounts or calcium mobilization in Itpkb(-/-) thymocytes. These data indicate that Itpkb and Ins(1,3,4,5) P-4 define an essential signaling pathway for T cell precursor responsiveness and development.

引用

页码：1136 / 1143

页数：8

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