Development of antibody surrogates for the treatment of cancers and autoimmune disease

被引：12

作者：

Kodadek, Thomas ^{[1
,2
]}

机构：

[1] Scripps Res Inst, Dept Chem, Jupiter, FL 33458 USA

[2] Scripps Res Inst, Dept Canc Biol, Jupiter, FL 33458 USA

来源：

CURRENT OPINION IN CHEMICAL BIOLOGY | 2010年 / 14卷 / 06期

关键词：

MONOCLONAL-ANTIBODIES; ADAPTER IMMUNOTHERAPY; CELL; IDENTIFICATION; RITUXIMAB; DEPLETION; INTEGRIN;

D O I：

10.1016/j.cbpa.2010.07.002

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Some therapeutic monoclonal antibodies function by focusing the killing power of the immune system on particular cellular targets, a process known as antibody-dependent cell-mediated cytotoxicity (ADCC). There is considerable interest in developing small-molecule therapeutics that utilize this mechanism of action and so act as a kind of antibody surrogate. Progress and challenges. in this interesting field are reviewed here.

引用

页码：721 / 727

页数：7

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