Novel bromotyrosine alkaloids: Inhibitors of mycothiol S-conjugate amidase

被引：70

作者：

Nicholas, GM

Newton, GL

Fahey, RC

Bewley, CA ^{[1
]}

机构：

[1] NIDDK, Bioorgan Chem Lab, NIH, Bethesda, MD 20892 USA

[2] Univ Calif San Diego, Dept Chem & Biochem, La Jolla, CA 92093 USA

来源：

ORGANIC LETTERS | 2001年 / 3卷 / 10期

关键词：

D O I：

10.1021/ol015845+

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

[GRAPHICS] The novel alkaloids 1 and 4 were isolated from an Australian non-verongid sponge, Oceanapia sp, Compound 1 contains an unprecedented imidazolyl-quinolinone substructure attached to a bromotyrosine-derived spiro isoxazoline. Three other known alkaloids were isolated in addition to 1 and 4 and together represent the first examples of inhibitors of a new mycobacterial enzyme mycothiol S-conjugate amidase (MCA).

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页码：1543 / 1545

页数：3

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