Multidrug-resistance protein 1 in focal cortical dysplasia

被引：94

作者：

Sisodiya, SM ^{[1
]}

Lin, WR

Squier, MV

Thom, M

机构：

[1] UCL, Inst Neurol, Dept Clin Neurol, Epilepsy Res Grp, London WC1N 3BG, England

[2] UCL, Inst Neurol, Dept Neuropathol, London WC1N 3BG, England

[3] Radcliffe Infirm, Dept Neuropathol, Oxford OX2 6HE, England

来源：

LANCET | 2001年 / 357卷 / 9249期

关键词：

D O I：

10.1016/S0140-6736(00)03573-X

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Drug resistance in epilepsy is poorly understood. We used routine immunohistochemistry to assess overexpression of a multidrug-resistance protein in dysplastic neurons, glia, and around vessels in surgically resected epileptogenic human brain tissue. We showed non-tumoral overexpression of this multidrug-resistance protein, which might contribute to drug resistance in epilepsy caused by focal cortical dysplasia.

引用

页码：42 / 43

页数：2

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