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Multivalency and the mode of action of bacterial sialidases
被引:60
作者
:
Thobhani, S
论文数:
0
引用数:
0
h-index:
0
机构:
Univ Georgia, Complex Carbohydrate Res Ctr, Athens, GA 30602 USA
Univ Georgia, Complex Carbohydrate Res Ctr, Athens, GA 30602 USA
Thobhani, S
[
1
]
Ember, B
论文数:
0
引用数:
0
h-index:
0
机构:
Univ Georgia, Complex Carbohydrate Res Ctr, Athens, GA 30602 USA
Univ Georgia, Complex Carbohydrate Res Ctr, Athens, GA 30602 USA
Ember, B
[
1
]
Siriwardena, A
论文数:
0
引用数:
0
h-index:
0
机构:
Univ Georgia, Complex Carbohydrate Res Ctr, Athens, GA 30602 USA
Univ Georgia, Complex Carbohydrate Res Ctr, Athens, GA 30602 USA
Siriwardena, A
[
1
]
Boons, GJ
论文数:
0
引用数:
0
h-index:
0
机构:
Univ Georgia, Complex Carbohydrate Res Ctr, Athens, GA 30602 USA
Univ Georgia, Complex Carbohydrate Res Ctr, Athens, GA 30602 USA
Boons, GJ
[
1
]
机构
:
[1]
Univ Georgia, Complex Carbohydrate Res Ctr, Athens, GA 30602 USA
来源
:
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
|
2003年
/ 125卷
/ 24期
关键词
:
D O I
:
10.1021/ja029759w
中图分类号
:
O6 [化学];
学科分类号
:
0703 ;
摘要
:
Although complex modular proteins are encountered frequently in a variety of biological systems, their occurrence in biocatalysis has not been widely appreciated. Here, we describe that bacterial sialidases, which have both a catalytic and carbohydrate-binding domain, can hydrolyze polyvalent substrates with much greater catalytic efficiency than their monovalent counterparts. The enhancement of catalytic efficiency was due to a much smaller Michaelis constant and rationalized by a model in which the catalytic and lectin domains interact simultaneously with the polyvalent substrate, leading to an enhancement of affinity. Inhibition studies have shown that galactosides released by the action of the sialidase can act as the ligand for the lectin domain. This knowledge has been exploited in the design of a potent polyvalent inhibitor of the sialidase of Vibrio cholerae, which displayed exquisite selectivities for sialidases that have a lectin domain. Copyright © 2003 American Chemical Society.
引用
收藏
页码:7154 / 7155
页数:2
相关论文
共 19 条
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Pseudomonas cellulose-binding domains mediate their effects by increasing enzyme substrate proximity
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0
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Newcastle Univ, Dept Biol & Nutr Sci, Newcastle Upon Tyne NE1 7RU, Tyne & Wear, England
Bolam, DN
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0
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机构:
Newcastle Univ, Dept Biol & Nutr Sci, Newcastle Upon Tyne NE1 7RU, Tyne & Wear, England
Ciruela, A
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0
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0
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0
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Newcastle Univ, Dept Biol & Nutr Sci, Newcastle Upon Tyne NE1 7RU, Tyne & Wear, England
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0
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0
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0
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Newcastle Univ, Dept Biol & Nutr Sci, Newcastle Upon Tyne NE1 7RU, Tyne & Wear, England
Simpson, P
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Williamson, MP
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0
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0
h-index:
0
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Newcastle Univ, Dept Biol & Nutr Sci, Newcastle Upon Tyne NE1 7RU, Tyne & Wear, England
Williamson, MP
;
Rixon, JE
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0
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0
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0
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Newcastle Univ, Dept Biol & Nutr Sci, Newcastle Upon Tyne NE1 7RU, Tyne & Wear, England
Rixon, JE
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Boraston, A
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0
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0
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Newcastle Univ, Dept Biol & Nutr Sci, Newcastle Upon Tyne NE1 7RU, Tyne & Wear, England
Boraston, A
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Hazlewood, GP
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Newcastle Univ, Dept Biol & Nutr Sci, Newcastle Upon Tyne NE1 7RU, Tyne & Wear, England
Hazlewood, GP
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Gilbert, HJ
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Newcastle Univ, Dept Biol & Nutr Sci, Newcastle Upon Tyne NE1 7RU, Tyne & Wear, England
Newcastle Univ, Dept Biol & Nutr Sci, Newcastle Upon Tyne NE1 7RU, Tyne & Wear, England
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UNIV BATH,SCH BIOL & BIOCHEM,BATH BA2 7AY,AVON,ENGLAND
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UNIV BATH,SCH BIOL & BIOCHEM,BATH BA2 7AY,AVON,ENGLAND
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UNIV BATH,SCH BIOL & BIOCHEM,BATH BA2 7AY,AVON,ENGLAND
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UNIV BATH,DEPT BIOCHEM,BATH BA2 7AY,AVON,ENGLAND
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UNIV BATH,DEPT BIOCHEM,BATH BA2 7AY,AVON,ENGLAND
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UNIV BATH,DEPT BIOCHEM,BATH BA2 7AY,AVON,ENGLAND
Vasella, A
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Laver, WG
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UNIV BATH,DEPT BIOCHEM,BATH BA2 7AY,AVON,ENGLAND
Laver, WG
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Vimr, ER
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UNIV BATH,DEPT BIOCHEM,BATH BA2 7AY,AVON,ENGLAND
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UNIV BATH,SCH BIOL & BIOCHEM,BATH BA2 7AY,AVON,ENGLAND
GASKELL, A
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CRENNELL, S
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UNIV BATH,SCH BIOL & BIOCHEM,BATH BA2 7AY,AVON,ENGLAND
UNIV BATH,SCH BIOL & BIOCHEM,BATH BA2 7AY,AVON,ENGLAND
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UNIV BATH,SCH BIOL & BIOCHEM,BATH BA2 7AY,AVON,ENGLAND
UNIV BATH,SCH BIOL & BIOCHEM,BATH BA2 7AY,AVON,ENGLAND
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Stanford Univ, Dept Chem, Stanford, CA 94305 USA
Stanford Univ, Dept Chem, Stanford, CA 94305 USA
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Stanford Univ, Dept Chem, Stanford, CA 94305 USA
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Univ Wisconsin, Dept Biochem, Madison, WI 53706 USA
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Griffith Univ, Ctr Biomol Sci & Drug Discovery, Nathan, Qld 9726, Australia
Griffith Univ, Ctr Biomol Sci & Drug Discovery, Nathan, Qld 9726, Australia
Klefel, MJ
;
von Itzstein, M
论文数:
0
引用数:
0
h-index:
0
机构:
Griffith Univ, Ctr Biomol Sci & Drug Discovery, Nathan, Qld 9726, Australia
Griffith Univ, Ctr Biomol Sci & Drug Discovery, Nathan, Qld 9726, Australia
von Itzstein, M
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CHEMICAL REVIEWS,
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102
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←
1
2
→
共 19 条
[1]
Pseudomonas cellulose-binding domains mediate their effects by increasing enzyme substrate proximity
[J].
Bolam, DN
论文数:
0
引用数:
0
h-index:
0
机构:
Newcastle Univ, Dept Biol & Nutr Sci, Newcastle Upon Tyne NE1 7RU, Tyne & Wear, England
Bolam, DN
;
Ciruela, A
论文数:
0
引用数:
0
h-index:
0
机构:
Newcastle Univ, Dept Biol & Nutr Sci, Newcastle Upon Tyne NE1 7RU, Tyne & Wear, England
Ciruela, A
;
McQueen-Mason, S
论文数:
0
引用数:
0
h-index:
0
机构:
Newcastle Univ, Dept Biol & Nutr Sci, Newcastle Upon Tyne NE1 7RU, Tyne & Wear, England
McQueen-Mason, S
;
Simpson, P
论文数:
0
引用数:
0
h-index:
0
机构:
Newcastle Univ, Dept Biol & Nutr Sci, Newcastle Upon Tyne NE1 7RU, Tyne & Wear, England
Simpson, P
;
Williamson, MP
论文数:
0
引用数:
0
h-index:
0
机构:
Newcastle Univ, Dept Biol & Nutr Sci, Newcastle Upon Tyne NE1 7RU, Tyne & Wear, England
Williamson, MP
;
Rixon, JE
论文数:
0
引用数:
0
h-index:
0
机构:
Newcastle Univ, Dept Biol & Nutr Sci, Newcastle Upon Tyne NE1 7RU, Tyne & Wear, England
Rixon, JE
;
Boraston, A
论文数:
0
引用数:
0
h-index:
0
机构:
Newcastle Univ, Dept Biol & Nutr Sci, Newcastle Upon Tyne NE1 7RU, Tyne & Wear, England
Boraston, A
;
Hazlewood, GP
论文数:
0
引用数:
0
h-index:
0
机构:
Newcastle Univ, Dept Biol & Nutr Sci, Newcastle Upon Tyne NE1 7RU, Tyne & Wear, England
Hazlewood, GP
;
Gilbert, HJ
论文数:
0
引用数:
0
h-index:
0
机构:
Newcastle Univ, Dept Biol & Nutr Sci, Newcastle Upon Tyne NE1 7RU, Tyne & Wear, England
Newcastle Univ, Dept Biol & Nutr Sci, Newcastle Upon Tyne NE1 7RU, Tyne & Wear, England
Gilbert, HJ
.
BIOCHEMICAL JOURNAL,
1998,
331
:775
-781
[2]
BACTERIAL SIALIDASES - ROLES IN PATHOGENICITY AND NUTRITION
[J].
CORFIELD, T
论文数:
0
引用数:
0
h-index:
0
机构:
Department of Medicine Laboratories, Bristol Royal Infirmary
CORFIELD, T
.
GLYCOBIOLOGY,
1992,
2
(06)
:509
-521
[3]
CRYSTAL-STRUCTURE OF VIBRIO-CHOLERAE NEURAMINIDASE REVEALS DUAL LECTIN-LIKE DOMAINS IN ADDITION TO THE CATALYTIC DOMAIN
[J].
CRENNELL, S
论文数:
0
引用数:
0
h-index:
0
机构:
UNIV BATH,SCH BIOL & BIOCHEM,BATH BA2 7AY,AVON,ENGLAND
CRENNELL, S
;
GARMAN, E
论文数:
0
引用数:
0
h-index:
0
机构:
UNIV BATH,SCH BIOL & BIOCHEM,BATH BA2 7AY,AVON,ENGLAND
GARMAN, E
;
LAVER, G
论文数:
0
引用数:
0
h-index:
0
机构:
UNIV BATH,SCH BIOL & BIOCHEM,BATH BA2 7AY,AVON,ENGLAND
LAVER, G
;
VIMR, E
论文数:
0
引用数:
0
h-index:
0
机构:
UNIV BATH,SCH BIOL & BIOCHEM,BATH BA2 7AY,AVON,ENGLAND
VIMR, E
;
论文数:
引用数:
h-index:
机构:
TAYLOR, G
.
STRUCTURE,
1994,
2
(06)
:535
-544
[4]
The structures of Salmonella typhimurium LT2 neuraminidase and its complexes with three inhibitors at high resolution
[J].
Crennell, SJ
论文数:
0
引用数:
0
h-index:
0
机构:
UNIV BATH,DEPT BIOCHEM,BATH BA2 7AY,AVON,ENGLAND
Crennell, SJ
;
Garman, EF
论文数:
0
引用数:
0
h-index:
0
机构:
UNIV BATH,DEPT BIOCHEM,BATH BA2 7AY,AVON,ENGLAND
Garman, EF
;
Philippon, C
论文数:
0
引用数:
0
h-index:
0
机构:
UNIV BATH,DEPT BIOCHEM,BATH BA2 7AY,AVON,ENGLAND
Philippon, C
;
Vasella, A
论文数:
0
引用数:
0
h-index:
0
机构:
UNIV BATH,DEPT BIOCHEM,BATH BA2 7AY,AVON,ENGLAND
Vasella, A
;
Laver, WG
论文数:
0
引用数:
0
h-index:
0
机构:
UNIV BATH,DEPT BIOCHEM,BATH BA2 7AY,AVON,ENGLAND
Laver, WG
;
Vimr, ER
论文数:
0
引用数:
0
h-index:
0
机构:
UNIV BATH,DEPT BIOCHEM,BATH BA2 7AY,AVON,ENGLAND
Vimr, ER
;
Taylor, GL
论文数:
0
引用数:
0
h-index:
0
机构:
UNIV BATH,DEPT BIOCHEM,BATH BA2 7AY,AVON,ENGLAND
Taylor, GL
.
JOURNAL OF MOLECULAR BIOLOGY,
1996,
259
(02)
:264
-280
[5]
THE 3 DOMAINS OF A BACTERIAL SIALIDASE - A BETA-PROPELLER, AN IMMUNOGLOBULIN MODULE AND A GALACTOSE-BINDING JELLY-ROLL
[J].
GASKELL, A
论文数:
0
引用数:
0
h-index:
0
机构:
UNIV BATH,SCH BIOL & BIOCHEM,BATH BA2 7AY,AVON,ENGLAND
UNIV BATH,SCH BIOL & BIOCHEM,BATH BA2 7AY,AVON,ENGLAND
GASKELL, A
;
CRENNELL, S
论文数:
0
引用数:
0
h-index:
0
机构:
UNIV BATH,SCH BIOL & BIOCHEM,BATH BA2 7AY,AVON,ENGLAND
UNIV BATH,SCH BIOL & BIOCHEM,BATH BA2 7AY,AVON,ENGLAND
CRENNELL, S
;
TAYLOR, G
论文数:
0
引用数:
0
h-index:
0
机构:
UNIV BATH,SCH BIOL & BIOCHEM,BATH BA2 7AY,AVON,ENGLAND
UNIV BATH,SCH BIOL & BIOCHEM,BATH BA2 7AY,AVON,ENGLAND
TAYLOR, G
.
STRUCTURE,
1995,
3
(11)
:1197
-1205
[6]
DIMERIZATION OF CELL-SURFACE RECEPTORS IN SIGNAL-TRANSDUCTION
[J].
HELDIN, CH
论文数:
0
引用数:
0
h-index:
0
机构:
Ludwig Institute for Cancer Research Biomedical Center
HELDIN, CH
.
CELL,
1995,
80
(02)
:213
-223
[7]
Houseman BT, 2002, TOP CURR CHEM, V218, P1
[8]
Modular enzymes
[J].
Khosla, C
论文数:
0
引用数:
0
h-index:
0
机构:
Stanford Univ, Dept Chem, Stanford, CA 94305 USA
Stanford Univ, Dept Chem, Stanford, CA 94305 USA
Khosla, C
;
Harbury, PB
论文数:
0
引用数:
0
h-index:
0
机构:
Stanford Univ, Dept Chem, Stanford, CA 94305 USA
Harbury, PB
.
NATURE,
2001,
409
(6817)
:247
-252
[9]
Synthetic multivalent ligands in the exploration of cell-surface interactions
[J].
Kiessling, LL
论文数:
0
引用数:
0
h-index:
0
机构:
Univ Wisconsin, Dept Biochem, Madison, WI 53706 USA
Kiessling, LL
;
Gestwicki, JE
论文数:
0
引用数:
0
h-index:
0
机构:
Univ Wisconsin, Dept Biochem, Madison, WI 53706 USA
Gestwicki, JE
;
Strong, LE
论文数:
0
引用数:
0
h-index:
0
机构:
Univ Wisconsin, Dept Biochem, Madison, WI 53706 USA
Strong, LE
.
CURRENT OPINION IN CHEMICAL BIOLOGY,
2000,
4
(06)
:696
-703
[10]
Recent advances in the synthesis of sialic acid derivatives and sialylmimetics as biological probes
[J].
Klefel, MJ
论文数:
0
引用数:
0
h-index:
0
机构:
Griffith Univ, Ctr Biomol Sci & Drug Discovery, Nathan, Qld 9726, Australia
Griffith Univ, Ctr Biomol Sci & Drug Discovery, Nathan, Qld 9726, Australia
Klefel, MJ
;
von Itzstein, M
论文数:
0
引用数:
0
h-index:
0
机构:
Griffith Univ, Ctr Biomol Sci & Drug Discovery, Nathan, Qld 9726, Australia
Griffith Univ, Ctr Biomol Sci & Drug Discovery, Nathan, Qld 9726, Australia
von Itzstein, M
.
CHEMICAL REVIEWS,
2002,
102
(02)
:471
-490
←
1
2
→