Epigenetics - Perceptive enzymes

被引:40
作者
Ferguson-Smith, Anne C.
Greally, John M.
机构
[1] Univ Cambridge, Dept Physiol Dev & Neurosci, Cambridge CB2 3DY, England
[2] Albert Einstein Coll Med, Dept Med Hematol, Bronx, NY 10461 USA
[3] Albert Einstein Coll Med, Dept Mol Genet, Bronx, NY 10461 USA
基金
英国医学研究理事会;
关键词
D O I
10.1038/449148a
中图分类号
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号
07 ; 0710 ; 09 ;
摘要
Adding methyl groups to DNA is a way of regulating some genes and genomic sequences. Structural analysis reveals that the enzyme complex that mediates this process shows unexpected sequence specificity.
引用
收藏
页码:148 / 149
页数:2
相关论文
共 9 条
[1]   Dnmt3L and the establishment of maternal genomic imprints [J].
Bourc'his, D ;
Xu, GL ;
Lin, CS ;
Bollman, B ;
Bestor, TH .
SCIENCE, 2001, 294 (5551) :2536-2539
[2]   Meiotic catastrophe and retrotransposon reactivation in male germ cells lacking Dnmt3L [J].
Bourc'his, D ;
Bestor, TH .
NATURE, 2004, 431 (7004) :96-99
[3]   Mechanisms regulating imprinted genes in clusters [J].
Edwards, Carol A. ;
Ferguson-Smith, Anne C. .
CURRENT OPINION IN CELL BIOLOGY, 2007, 19 (03) :281-289
[4]   Epigenomics: Beyond CpG islands [J].
Fazzari, MJ ;
Greally, JM .
NATURE REVIEWS GENETICS, 2004, 5 (06) :446-455
[5]   Enzymatic properties of recombinant Dnmt3a DNA methyltransferase from mouse: The enzyme modifies DNA in a non-processive manner and also methylates non-CpA sites [J].
Gowher, H ;
Jeltsch, A .
JOURNAL OF MOLECULAR BIOLOGY, 2001, 309 (05) :1201-1208
[6]   Structure of Dnmt3a bound to Dnmt3L suggests a model for de novo DNA methylation [J].
Jia, Da ;
Jurkowska, Renata Z. ;
Zhang, Xing ;
Jeltsch, Albert ;
Cheng, Xiaodong .
NATURE, 2007, 449 (7159) :248-U13
[7]   Essential role for de novo DNA methyltransferase Dnmt3a in paternal and maternal imprinting [J].
Kaneda, M ;
Okano, M ;
Hata, K ;
Sado, T ;
Tsujimoto, N ;
Li, E ;
Sasaki, H .
NATURE, 2004, 429 (6994) :900-903
[8]   The human genome browser at UCSC [J].
Kent, WJ ;
Sugnet, CW ;
Furey, TS ;
Roskin, KM ;
Pringle, TH ;
Zahler, AM ;
Haussler, D .
GENOME RESEARCH, 2002, 12 (06) :996-1006
[9]   DNMT3L connects unmethylated lysine 4 of histone H3 to de novo methylation of DNA [J].
Ooi, Steen K. T. ;
Qiu, Chen ;
Bernstein, Emily ;
Li, Keqin ;
Jia, Da ;
Yang, Zhe ;
Erdjument-Bromage, Hediye ;
Tempst, Paul ;
Lin, Shau-Ping ;
Allis, C. David ;
Cheng, Xiaodong ;
Bestor, Timothy H. .
NATURE, 2007, 448 (7154) :714-U13