Protection studies against Marek's disease using baculovirus-expressed glycoproteins B and C of Marek's disease virus type 1

被引：8

作者：

Jang, HK ^{[1
]}

Kitazawa, T ^{[1
]}

Ono, M ^{[1
]}

Kawaguchi, Y ^{[1
]}

Maeda, K ^{[1
]}

Yokoyama, N ^{[1
]}

Tohya, Y ^{[1
]}

Niikura, M ^{[1
]}

Mikami, T ^{[1
]}

机构：

[1] UNIV TOKYO, FAC AGR, DEPT VET MICROBIOL, BUNKYO KU, TOKYO 113, JAPAN

来源：

AVIAN PATHOLOGY | 1996年 / 25卷 / 01期

关键词：

D O I：

10.1080/03079459608419116

中图分类号：

S85 [动物医学（兽医学）];

学科分类号：

0906 ;

摘要：

Glycoproteins B (MDV1-gB) and C (MDV1-gC) of Marek's disease virus type 1 (MDV 1) expressed by baculovirus recombinants [rAcNPV(s)] were investigated for their ability to confer protective immunity in chickens against virulent MDV1 challenge. Immunization of chickens with rAcNPV-expressed MDV1-gB induced antibody against MDV1 and resulted in strong protection against the lethal challenge with MDV1. In contrast, immunization of chickens with rAcNPV-expressed MDV1-gC induced antibody against MDV1, but failed to protect against challenge with the virulent MDV1. Go-immunization with both rAcNPV-expressed MDV1-gB and MDV1-gC seemed to show no synergistic effect.

引用

页码：5 / 24

页数：20

共 61 条

[1] NUCLEOTIDE-SEQUENCE OF THE MAREKS-DISEASE VIRUS (MDV) RB-1B-A ANTIGEN GENE AND THE IDENTIFICATION OF THE MDV A ANTIGEN AS THE HERPES-SIMPLEX VIRUS-1 GLYCOPROTEIN-C HOMOLOG [J].

BINNS, MM ;

ROSS, NLJ .

VIRUS RESEARCH, 1989, 12 (04) :371-382

[2] INSERTION OF THE FUSION GENE FROM NEWCASTLE-DISEASE VIRUS INTO A NONESSENTIAL REGION IN THE TERMINAL REPEATS OF FOWLPOX VIRUS AND DEMONSTRATION OF PROTECTIVE IMMUNITY INDUCED BY THE RECOMBINANT [J].

BOURSNELL, MEG ;

GREEN, PF ;

CAMPBELL, JIA ;

DEUTER, A ;

PETERS, RW ;

TOMLEY, FM ;

SAMSON, ACR ;

CHAMBERS, P ;

EMMERSON, PT ;

BINNS, MM .

JOURNAL OF GENERAL VIROLOGY, 1990, 71 :621-628

[3] GENE SEQUENCE AND MAPPING DATA FROM MAREKS-DISEASE VIRUS AND HERPESVIRUS OF TURKEYS - IMPLICATIONS FOR HERPESVIRUS CLASSIFICATION [J].

BUCKMASTER, AE ;

SCOTT, SD ;

SANDERSON, MJ ;

BOURSNELL, MEG ;

ROSS, NLJ ;

BINNS, MM .

JOURNAL OF GENERAL VIROLOGY, 1988, 69 :2033-2042

[4] ROLE OF GLYCOPROTEIN-B OF HERPES-SIMPLEX VIRUS TYPE-1 IN VIRAL ENTRY AND CELL-FUSION [J].

CAL, WH ;

GU, BH ;

PERSON, S .

JOURNAL OF VIROLOGY, 1988, 62 (08) :2596-2604

[5] EXPRESSION OF HERPES-SIMPLEX VIRUS-1 GLYCOPROTEIN-B BY A RECOMBINANT VACCINIA VIRUS AND PROTECTION OF MICE AGAINST LETHAL HERPES-SIMPLEX VIRUS-1 INFECTION [J].

CANTIN, EM ;

EBERLE, R ;

BALDICK, JL ;

MOSS, B ;

WILLEY, DE ;

NOTKINS, AL ;

OPENSHAW, H .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1987, 84 (16) :5908-5912

[6] INVERTED REPEAT NUCLEOTIDE-SEQUENCES IN THE GENOMES OF MAREK DISEASE VIRUS AND THE HERPESVIRUS OF THE TURKEY [J].

CEBRIAN, J ;

KASCHKADIERICH, C ;

BERTHELOT, N ;

SHELDRICK, P .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA-BIOLOGICAL SCIENCES, 1982, 79 (02) :555-558

[7] EXPRESSION OF THE MAREKS-DISEASE VIRUS HOMOLOG OF HERPES-SIMPLEX VIRUS GLYCOPROTEIN-B IN ESCHERICHIA-COLI AND ITS IDENTIFICATION AS B-ANTIGEN [J].

CHEN, XB ;

VELICER, LF .

JOURNAL OF VIROLOGY, 1992, 66 (07) :4390-4398

[8] ATTENUATION WITH LOSS OF ONCOGENICITY OF HERPES-TYPE VIRUS OF MAREKS DISEASE (STRAIN HPRS-16) ON PASSAGE IN CELL CULTURE [J].

CHURCHILL, AE ;

CHUBB, RC ;

BAXENDALE, W .

JOURNAL OF GENERAL VIROLOGY, 1969, 4 :557-+

[9]

Coussens P M, 1990, Virus Genes, V3, P291, DOI 10.1007/BF00569037

[10] STRUCTURE AND COMPLETE NUCLEOTIDE-SEQUENCE OF THE MAREKS-DISEASE HERPESVIRUS GP57-65 GENE [J].

COUSSENS, PM ;

VELICER, LF .

JOURNAL OF VIROLOGY, 1988, 62 (07) :2373-2379

← 1 2 3 4 5 6 7 →