Cytokines, Masticatory Muscle Inflammation, and Pain: an Update

被引:25
作者
Ayoub, Sara [1 ]
Berberi, Antoine [2 ]
Fayyad-Kazan, Mohammad [3 ,4 ]
机构
[1] Lebanese Univ, Fac Med Dent, Dept Prosthodont, Beirut, Lebanon
[2] Lebanese Univ, Fac Med Dent, Dept Oral & Maxillofacial Surg, Beirut, Lebanon
[3] Lebanese Univ, Fac Sci 1, Lab Canc Biol & Mol Immunol, Beirut, Lebanon
[4] Lebanese Amer Univ, Sch Arts & Sci, Dept Nat Sci, Beirut, Lebanon
关键词
Cytokine; Inflammation; Pain; Hyperalgesia; Allodynia; Masticatory muscle; TUMOR-NECROSIS-FACTOR; TRIGEMINAL GANGLION CONTRIBUTES; IL-1 RECEPTOR ANTAGONIST; GROWTH-FACTOR-BETA; MASSETER MUSCLE; FACTOR-ALPHA; TEMPOROMANDIBULAR DISORDERS; EXPRESSION; INTERLEUKIN-6; ACTIVATION;
D O I
10.1007/s12031-020-01491-1
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
070307 [化学生物学]; 071010 [生物化学与分子生物学];
摘要
Cytokines are proteins secreted by diverse types of immune and non-immune cells and play a role in the communication between the immune and nervous systems. Cytokines include lymphokines, monokines, chemokines, interleukins, interferons, colony stimulating factors, and growth factors. They can be both pro- and anti-inflammatory and have autocrine, paracrine, and endocrine activities. These proteins are involved in initiation and persistence of pain, and the progress of hyperalgesia and allodynia, upon stimulating nociceptive sensory neurons, and inducing central sensitization. The objective of this review is to discuss several types of pro- and anti-inflammatory mediators and their relation with inflammatory pain in masticatory muscles.
引用
收藏
页码:790 / 795
页数:6
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