Combined circuit/device modeling and simulation of integrated microfluidic systems

被引:47
作者
Chatterjee, AN [1 ]
Aluru, NR [1 ]
机构
[1] Univ Illinois, Beckman Inst Adv Sci & Technol, Dept Mech & Ind Engn, Urbana, IL 61801 USA
基金
美国国家科学基金会;
关键词
circuit-modeling; lab-on-a-chip; microfluidics; simulation;
D O I
10.1109/JMEMS.2004.839025
中图分类号
TM [电工技术]; TN [电子技术、通信技术];
学科分类号
0808 ; 0809 ;
摘要
A combined circuit/device model for the analysis of integrated microfluidic systems is presented. The complete model of an integrated microfluidic device incorporates modeling of fluidic transport, chemical reaction, reagent mixing, and separation. The fluidic flow is generated by an applied electrical field or by a combined electrical field and pressure gradient. In the proposed circuit/device model, the fluidic network has been represented by a circuit model and the functional units of the mu-TAS (micro Total Analysis System) have been represented by appropriate device models. We demonstrate the integration of the circuit and the device models by using an example, where the output from the fluidic transport module serves as the input for the other modules such as mixing, chemical reaction and separation. The combined circuit/device model can be used for analysis and design of entire microfluidic systems with very little computational expense, while maintaining the desired level of accuracy.
引用
收藏
页码:81 / 95
页数:15
相关论文
共 42 条
[1]  
ADJARI A, 2001, PHYS REV E, V65
[2]   Polymer microfluidic devices [J].
Becker, H ;
Locascio, LE .
TALANTA, 2002, 56 (02) :267-287
[3]  
CASINOVI G, 2001, TECHN P 2001 INT C M, P112
[4]   Multiport flow-control system for lab-on-a-chip microfluidic devices [J].
Chien, RL ;
Parce, JW .
FRESENIUS JOURNAL OF ANALYTICAL CHEMISTRY, 2001, 371 (02) :106-111
[5]  
COLBURN JC, 1992, CAPILLARY ELECTROPHO
[6]  
Davies J. T., 1966, INTERFACIAL PHENOMEN
[7]   Electrochemistry and microsystems [J].
Ehrfeld, W .
ELECTROCHIMICA ACTA, 2003, 48 (20-22) :2857-2868
[8]   Theoretical considerations of chemical reactions in micro-reactors operating under electroosmotic and electrophoretic control [J].
Fletcher, PDI ;
Haswell, SJ ;
Paunov, VN .
ANALYST, 1999, 124 (09) :1273-1282
[9]   Electrokinetic control of a chemical reaction in a lab-on-a-chip micro-reactor: measurement and quantitative modelling [J].
Fletcher, PDI ;
Haswell, SJ ;
Zhang, XL .
LAB ON A CHIP, 2002, 2 (02) :102-112
[10]   Electrical conductivity particle detector for use in biological and chemical micro-analysis systems [J].
Gale, BK ;
Caldwell, KD ;
Frazier, AB .
MICROFLUIDIC DEVICES AND SYSTEMS, 1998, 3515 :230-241