Prevalence of extended-spectrum β-lactamase-producing Gram-negative bacteria in septicaemic neonates in a tertiary care hospital

被引:107
作者
Jain, A [1 ]
Roy, I
Gupta, MK
Kumar, M
Agarwal, SK
机构
[1] King Georges Mem Coll, Dept Microbiol, Lucknow 226003, Uttar Pradesh, India
[2] King Georges Mem Coll, Dept Paediat, Lucknow 226003, Uttar Pradesh, India
关键词
D O I
10.1099/jmm.0.04966-0
中图分类号
Q93 [微生物学];
学科分类号
071005 ; 100705 ;
摘要
The present study was undertaken to investigate the high incidence of multiresistant Gram-negative bacilli causing neonatal septicaemia. Samples of neonatal blood from 728 suspected cases were obtained in brain heart infusion broth with sodium polyanethol sulfonate. All Gram-negative rods isolated were subsequently subjected to routine antimicrobial susceptibility testing and tests for extended-spectrum P-lactamase (ESBL) production, as per NCCLS recommendations. ESBL was detected in 86.6% of Klebsiella spp., 73.4% of Enterobacter spp. and 63.6% of Escherichia coli strains. It was also observed that 74.4-80.9% of these ESBL producers were resistant to cefotaxime and 47.6-59.5% were resistant to ceftazidime in routine susceptibility testing. Some ESBL producers (36.3-61.5%) were found to be susceptible to either or both cephalosporins used in this study. It is concluded that indiscriminate use of third-generation cephalosporins may be responsible for the selection of ESBL-producing multiresistant strains in the neonatal intensive-care unit (NICU).
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页码:421 / 425
页数:5
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