Dynamic of pneumococcal nasopharyngeal carriage in children with acute otitis media following PCV7 introduction in France

被引：59

作者：

Cohen, R. ^{[1
]}

Levy, C.

Bonnet, E.

Grondin, S. ^{[2
]}

Desvignes, V.

Lecuyer, A.

Fritzell, B.

Varon, E. ^{[2
]}

机构：

[1] Ctr Hosp Intercommunal Creteil, Dept Microbiol, Microbiol Serv, F-94000 Creteil, France

[2] HEGP, AP HP, CNRP, Paris, France

来源：

VACCINE | 2010年 / 28卷 / 37期

关键词：

Pneumococcal nasopharyngeal carriage; Children; Seven valent pneumococcal conjugate vaccine; STREPTOCOCCUS-PNEUMONIAE; CONJUGATE VACCINE; SEROTYPES; IMPACT; COLONIZATION; COMMUNITIES; DISEASE;

D O I：

10.1016/j.vaccine.2009.05.037

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

To determine whether the use of seven valent pneumococcal conjugate vaccine (PCV7) caused a shift in the Streptococcus pneumoniae serotypes distribution and whether it modified the resistance to antibiotics, 3291 nasopharyngeal swabs were obtained between 2001 and 2006, from children aged 6-24 months with acute otitis media. Following the implementation of PCV7, we observed a slight reduction in the overall pneumococcal carriage, a marked decrease of vaccine serotypes, an increase in non-vaccine serotypes carriage and a reduction in the carriage of penicillin non-susceptible strains. Most of the serotype 19A replacement was related to the clonal expansion of ST276 which was found to be the predominant ST among penicillin non-susceptible isolates. (C) 2010 Elsevier Ltd. All rights reserved.

引用

页码：6114 / 6121

页数：8

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