Dietary bioflavonoids induce apoptosis in human leukemia cells

被引：18

作者：

Matsui, J ^{[1
]}

Kiyokawa, N ^{[1
]}

Takenouchi, H ^{[1
]}

Taguchi, T ^{[1
]}

Suzuki, K ^{[1
]}

Shiozawa, Y ^{[1
]}

Saito, M ^{[1
]}

Tang, WR ^{[1
]}

Katagiri, YU ^{[1
]}

Okita, H ^{[1
]}

Fujimoto, J ^{[1
]}

机构：

[1] Natl Res Inst Child Hlth & Dev, Dept Dev Biol, Setagaya Ku, Tokyo 1548535, Japan

来源：

LEUKEMIA RESEARCH | 2005年 / 29卷 / 05期

基金：

日本学术振兴会;

关键词：

bioflavonoid; apoptosis; acute lymphoblastic leukemia; precursor-B-cell;

D O I：

10.1016/j.leukres.2004.11.015

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Dietary bioflavonoids are secondary metabolites of plants that are known to have a variety of bio-effects, including anti-cancer activity. In this study, we examined the effects of flavonoids on the growth of human leukemia cells and found that certain flavonoids induce apoptosis in a variety of human leukemia cells. The apoptosis induced by bioflavonoids was dose-dependent and was accompanied by a disruption of the mitochondrial transmembrane potential and the activation of caspase. Our data suggests that dietary bioflavonoids may be useful chemotherapeutic reagents for leukemia patients. (c) 2004 Elsevier Ltd. All rights reserved.

引用

页码：573 / 581

页数：9

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