Mitochondria as integrators of information in an early-evolving animal: insights from a triterpenoid metabolite

被引:14
作者
Blackstone, NW [1 ]
Kelly, MM
Haridas, V
Gutterman, JU
机构
[1] No Illinois Univ, Dept Biol Sci, De Kalb, IL 60115 USA
[2] Univ Texas, MD Anderson Canc Ctr, Dept Mol Therapeut, Houston, TX 77030 USA
关键词
avicins; cancer; hydroids; Podocoryna; reactive oxygen species; redox state;
D O I
10.1098/rspb.2004.2981
中图分类号
Q [生物科学];
学科分类号
07 ; 0710 ; 09 ;
摘要
Mitochondria have the capacity to integrate environmental signals and, in animals with active stem cell populations, trigger responses in terms of growth and growth form. Colonial hydroids, which consist of feeding polyps connected by tube-like stolons, were treated with avicins, triterpenoid electrophiles whose anti-cancer properties in human cells are mediated in part by mitochondria. In treated hydroids, both oxygen uptake and mitochondrial reactive oxygen species were diminished relative to controls, similar to that observed in human cells exposed to avicins. While untreated colonies exhibit more stolon branches and connections in the centre of the colony than at the periphery, treated colonies exhibit the opposite: fewer stolon branches in the centre of the colony than at the periphery. The resulting growth form suggests an inversion of the normal pattern of colony development mediated by mitochondrial and redox-related perturbations. An as-yet-uncharacterized gradient within the colony may determine the ultimate phenotypic effect of avicin perturbation.
引用
收藏
页码:527 / 531
页数:5
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