Flavanones: Citrus phytochemical with health-promoting properties

被引：327

作者：

Barreca, Davide ^{[1
]}

Gattuso, Giuseppe ^{[1
]}

Bellocco, Ersilia ^{[1
]}

Calderaro, Antonella ^{[1
]}

Trombetta, Domenico ^{[1
]}

Smeriglio, Antonella ^{[1
]}

Lagana, Giuseppina ^{[1
]}

Daglia, Maria ^{[2
]}

Meneghini, Silvia ^{[2
]}

Nabavi, Seyed Mohammad ^{[3
]}

机构：

[1] Univ Messina, Dept Chem Biol Pharmaceut & Environm Sci, Viale F Stagno dAlcontres 31, Messina, Italy

[2] Univ Pavia, Med Chem & Pharmaceut Technol Sect, Dept Drug Sci, Pavia, Italy

[3] Baqiyatallah Univ Med Sci, Appl Biotechnol Res Ctr, Tehran, Iran

来源：

BIOFACTORS | 2017年 / 43卷 / 04期

关键词：

flavanones; biosynthesis and metabolism; health promoting properties; anti-inflammatory activity; anticholesterolemic activity; degenerative diseases; ORANGE JUICE (POLY)PHENOLS; O-GLYCOSYL FLAVONOIDS; NF-KAPPA-B; RADICAL-SCAVENGING ACTIVITY; HUMAN SERUM-ALBUMIN; L. OSBECK JUICE; IN-VITRO; DOWN-REGULATION; AURANTIUM L; HESPERIDIN;

D O I：

10.1002/biof.1363

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

070307 [化学生物学]; 071010 [生物化学与分子生物学];

摘要：

Citrus fruit and juices represent one of the main sources of compounds with a high potential for health promoting properties. Among these compounds, flavanones (such as hesperetin, naringenin, eriodictyol, isosakuranetin, and their respective glycosides), which occur in quantities ranging from approximate to 180 to 740 mg/L (depending on the Citrus species and cultivar) are responsible for many biological activities. These compounds support and enhance the body's defenses against oxidative stress and help the organism in the prevention of cardiovascular diseases, atherosclerosis, and cancer. Moreover, among other properties, they also show anti-inflammatory, antiviral, and antimicrobial activities. This review analyzes the biochemistry, pharmacology, and biology of Citrus flavanones, emphasizing the occurrence in Citrus fruits and juices and their bioavailability, structure-function correlations and ability to modulate signal cascades both in vitro and in vivo. (c) 2017 BioFactors, 43(4):495-506, 2017

引用

页码：495 / 506

页数：12

共 94 条

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Hesperidin Inhibits Inflammatory Response Induced by Aeromonas hydrophila Infection and Alters CD4+/CD8+ T Cell Ratio [J].