Nonopsonic phagocytosis of erythrocytes infected with ring-stage Plasmodium falciparum

被引：27

作者：

Ayi, K

Patel, SN

Serghides, L

Smith, TG

Kain, KC

机构：

[1] Toronto Gen Hosp, Trop Dis Unit, Toronto, ON M5G 2C4, Canada

[2] Univ Toronto, Dept Med, Toronto, ON, Canada

[3] Univ Toronto, McLaughlin Rotman Ctr Global Hlth, McLaughlin Ctr Mol Med, Toronto, ON, Canada

来源：

INFECTION AND IMMUNITY | 2005年 / 73卷 / 04期

关键词：

D O I：

10.1128/IAI.73.4.2559-2563.2005

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Ring-stage parasitized erythrocytes (RPEs) were demonstrated to interact with effector cells of the innate immune system. With receptor blockade studies and CD36-null macrophages, human and murine macrophages were shown to phagocytose RPEs through the pattern recognition receptor CD36. These in vitro data implicate scavenger receptors in the clearance of RPEs.

引用

收藏

页码：2559 / 2563

页数：5

相关论文

共 30 条

[1] INTERCELLULAR-ADHESION MOLECULE-1 IS AN ENDOTHELIAL-CELL ADHESION RECEPTOR FOR PLASMODIUM-FALCIPARUM [J].

BERENDT, AR ;

SIMMONS, DL ;

TANSEY, J ;

NEWBOLD, CI ;

MARSH, K .

NATURE, 1989, 341 (6237) :57-59

[2] INDUCTION OF THE PROTEOLYTIC ACTIVITY OF A MEMBRANE-PROTEIN IN PLASMODIUM-FALCIPARUM BY PHOSPHATIDYL INOSITOL-SPECIFIC PHOSPHOLIPASE-C [J].

BRAUNBRETON, C ;

ROSENBERRY, TL ;

DASILVA, LP .

NATURE, 1988, 332 (6163) :457-459

[3] VLA-4 INTEGRIN CAN MEDIATE CD11 CD18-INDEPENDENT TRANSENDOTHELIAL MIGRATION OF HUMAN MONOCYTES [J].

CHULUYAN, HE ;

ISSEKUTZ, AC .

JOURNAL OF CLINICAL INVESTIGATION, 1993, 92 (06) :2768-2777

[4] Membrane modifications in erythrocytes parasitized by Plasmodium falciparum [J].

Deitsch, KW ;

Wellems, TE .

MOLECULAR AND BIOCHEMICAL PARASITOLOGY, 1996, 76 (1-2) :1-10

[5] Adhesion of normal and Plasmodium falciparum ring-infected erythrocytes to endothelial cells and the placenta involves the rhoptry-derived ring surface protein-2 [J].

Douki, JBL ;

Sterkers, Y ;

Lépolard, C ;

Traoré, B ;

Costa, FTM ;

Scherf, A ;

Gysin, J .

BLOOD, 2003, 101 (12) :5025-5032

[6]

Fadok VA, 1998, J IMMUNOL, V161, P6250

[7] A null mutation in murine CD36 reveals an important role in fatty acid and lipoprotein metabolism [J].

Febbraio, M ;

Abumrad, NA ;

Hajjar, DP ;

Sharma, K ;

Cheng, WL ;

Pearce, SFA ;

Silverstein, RL .

JOURNAL OF BIOLOGICAL CHEMISTRY, 1999, 274 (27) :19055-19062

[8] INTERACTION OF THE PEROXISOME-PROLIFERATOR-ACTIVATED RECEPTOR AND RETINOID X-RECEPTOR [J].

GEARING, KL ;

GOTTLICHER, M ;

TEBOUL, M ;

WIDMARK, E ;

GUSTAFSSON, JA .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1993, 90 (04) :1440-1444

[9] Phosphatidylserine (PS) induces PS receptor-mediated macropinocytosis and promotes clearance of apoptotic cells [J].

Hoffmann, PR ;

deCathelineau, AM ;

Ogden, CA ;

Leverrier, Y ;

Bratton, DL ;

Daleke, DL ;

Ridley, AJ ;

Fadok, VA ;

Henson, PM .

JOURNAL OF CELL BIOLOGY, 2001, 155 (04) :649-659

[10] CHARACTERIZATION OF PERMEATION PATHWAYS IN THE PLASMA-MEMBRANE OF HUMAN-ERYTHROCYTES INFECTED WITH EARLY STAGES OF PLASMODIUM-FALCIPARUM - ASSOCIATION WITH PARASITE DEVELOPMENT [J].

KUTNER, S ;

BREUER, WV ;

GINSBURG, H ;

ALEY, SB ;

CABANTCHIK, ZI .

JOURNAL OF CELLULAR PHYSIOLOGY, 1985, 125 (03) :521-527