Rapid tumor lysis in a patient with B-cell chronic lymphocytic leukemia and lymphocytosis treated with an anti-CD20 monoclonal antibody (IDEC-C2B8, rituximab)

被引：77

作者：

Jensen, M ^{[1
]}

Winkler, U ^{[1
]}

Manzke, O ^{[1
]}

Diehl, V ^{[1
]}

Engert, A ^{[1
]}

机构：

[1] Univ Cologne, Dept Internal Med 1, D-50931 Cologne, Germany

来源：

ANNALS OF HEMATOLOGY | 1998年 / 77卷 / 1-2期

关键词：

chronic lymphocytic leukemia; IDEC-C2B8; rituximab; tumor lysis syndrome; immunotherapy;

D O I：

10.1007/s002770050419

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

In this report we present a patient with B-cell chronic lymphocytic leukemia who developed an acute tumor lysis syndrome after administration of the human anti-CD20 antibody IDEC-C2B8 (RITUXIMAB) in standard dose of 375 mg/m(2). IDEC-C2B8 has been demonstrated to have only mild and tolerable side effects in patients with follicular lymphoma. In these trials patients with lymphocytosis > 5000/mu l were excluded. Physicians must be aware of this hitherto unreported phenomenon in patients with high CD20-positive blood counts.

引用

页码：89 / 91

页数：3

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