Effects of total body irradiation and cyclosporin A on the lethality of toxic shock syndrome toxin-1 in a rabbit model of toxic shock syndrome

被引：8

作者：

Dinges, MM

Gregerson, DS

Tripp, TJ

McCormick, JK

Schlievert, PM

机构：

[1] Univ Minnesota, Sch Med, Dept Microbiol, Minneapolis, MN 55455 USA

[2] Univ Minnesota, Sch Med, Dept Ophthalmol, Minneapolis, MN 55455 USA

来源：

JOURNAL OF INFECTIOUS DISEASES | 2003年 / 188卷 / 08期

关键词：

D O I：

10.1086/378514

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Toxic shock syndrome (TSS) may be mediated by super-antigen-activated T cells, a theory we tested in rabbits, which are more susceptible to the lethal effects of superantigens, such as TSS toxin-1 (TSST-1), than are mice. Rabbits exposed to 10 cGy of total body irradiation exhibited T cell deficiency, with profound depletion of splenic lymphocytes and circulating CD4(+) lymphocytes, as well as an inability to manifest delayed-type hypersensitivity. Nevertheless, these rabbits remained completely susceptible to TSST-1, indicating that TSS can occur in the setting of marked immunosuppression.

引用

页码：1142 / 1145

页数：4

共 15 条

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