Chemotherapy of human African trypanosomiasis: current and future prospects

被引：267

作者：

Fairlamb, AH ^{[1
]}

机构：

[1] Univ Dundee, Wellcome Trust Bioctr, Sch Life Sci, Div Biol Chem & Mol Microbiol, Dundee DD1 5EH, Scotland

来源：

TRENDS IN PARASITOLOGY | 2003年 / 19卷 / 11期

基金：

英国惠康基金;

关键词：

D O I：

10.1016/j.pt.2003.09.002

中图分类号：

R38 [医学寄生虫学]; Q [生物科学];

学科分类号：

07 ; 0710 ; 09 ; 100103 ;

摘要：

Three of the four currently approved drugs for the treatment of African trypanosomiasis (sleeping sickness) were developed over 50 years ago. All of the current therapies are unsatisfactory for various reasons, including unacceptable toxicity, poor efficacy, undesirable route of administration, and drug resistance. The possible modes of action of these drugs are briefly reviewed, as are the possible mechanisms of resistance. The intermediate and long-term prospects for the development of safer, effective drugs are discussed.

引用

收藏

页码：488 / 494

页数：7

相关论文

共 58 条

[21] SENSITIVITY OF PARASITES TO FREE-RADICAL DAMAGE BY ANTIPARASITIC DRUGS [J].

DOCAMPO, R .

CHEMICO-BIOLOGICAL INTERACTIONS, 1990, 73 (01) :1-27

[22] TbMP81 is required for RNA editing in Trypanosoma brucei [J].

Drozdz, M ;

Palazzo, SS ;

Salavati, R ;

O'Rear, J ;

Clayton, C ;

Stuart, K .

EMBO JOURNAL, 2002, 21 (07) :1791-1799

[23]

FAIRLAMB AH, 1992, ANNU REV MICROBIOL, V46, P695, DOI 10.1146/annurev.micro.46.1.695

[24] UPTAKE OF THE TRYPANOCIDAL DRUG SURAMIN BY BLOOD-STREAM FORMS OF TRYPANOSOMA-BRUCEI AND ITS EFFECT ON RESPIRATION AND GROWTH-RATE INVIVO [J].

FAIRLAMB, AH ;

BOWMAN, IBR .

MOLECULAR AND BIOCHEMICAL PARASITOLOGY, 1980, 1 (06) :315-333

[25] TRYPANOTHIONE IS THE PRIMARY TARGET FOR ARSENICAL DRUGS AGAINST AFRICAN TRYPANOSOMES [J].

FAIRLAMB, AH ;

HENDERSON, GB ;

CERAMI, A .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1989, 86 (08) :2607-2611

[26]

Fairlamb Alan H., 1997, P149

[27]

Fries DS, 2003, BURGERS MED CHEM DRU, P1033

[28] Glucose is toxic to glycosome-deficient trypanosomes [J].

Furuya, T ;

Kessler, P ;

Jardim, A ;

Schnaufer, A ;

Crudder, C ;

Parsons, M .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2002, 99 (22) :14177-14182

[29] Polyamine biosynthetic enzymes as drug targets in parasitic protozoa [J].

Heby, O ;

Roberts, SC ;

Ullman, B .

BIOCHEMICAL SOCIETY TRANSACTIONS, 2003, 31 :415-419

[30] COMBINATION CHEMOTHERAPY OF CNS TRYPANOSOMIASIS [J].

JENNINGS, FW .

ACTA TROPICA, 1993, 54 (3-4) :205-213

← 1 2 3 4 5 6 →