Antidesmone, a novel type isoquinoline alkaloid from Antidesma membranaceum (Euphorbiaceae)

被引：36

作者：

Buske, A

Busemann, S

Mühlbacher, J

Schmidt, J

Porzel, A

Bringmann, G ^{[1
]}

Adam, G

机构：

[1] Univ Wurzburg, Inst Plant Biochem, D-97074 Wurzburg, Germany

[2] Inst Plant Biochem, Dept Nat Prod Chem, D-06018 Halle, Germany

来源：

TETRAHEDRON | 1999年 / 55卷 / 04期

关键词：

D O I：

10.1016/S0040-4020(98)01107-7

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A novel type of tetrahydroisoquinoline alkaloid, antidesmone (1), was isolated from Antidesma membranaceum Mull. Arg.. The structure of 1 was determined to be (5S)-1-hydroxy-4-methoxy-3-methyl-5-octyl-5,6,7,8-tetrahydroisoquidolin-8-one by spectroscopic methods (MS, H-1, C-13 2D NMR, CD) and chemical derivatisation. The absolute (S)-configuration was determined by quantumchemical calculation of CD spectra. (C) 1999 Elsevier Science Ltd. All rights reserved.

引用

页码：1079 / 1086

页数：8

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