Total synthesis of (+/-)-2-pupukeanone

被引：30

作者：

Chang, NC

Chang, CK

机构：

[1] Department of Chemistry, National Sun Yat-Sen University, Kaohsiung

来源：

JOURNAL OF ORGANIC CHEMISTRY | 1996年 / 61卷 / 15期

关键词：

D O I：

10.1021/jo9603338

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A synthesis of (+/-)-2-pupukeanone (4) is described in which the pupukeanane skeleton is assembled by means of intramolecular cyclization of tosylate 11 and then the attachment of an isopropyl group at the appropriate position of the tricyclic ring system. The key intermediate 11 was constructed. via a sequence begining from readily available ketone 5 and proceeding through bicyclo[3.2.1]ketone 8 by regioselective ring expansion.

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页码：4967 / 4970

页数：4

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