Newly identified prions in budding yeast, and their possible functions

被引：55

作者：

Crow, Emily T. ^{[1
]}

Li, Liming ^{[1
]}

机构：

[1] Northwestern Univ, Feinberg Sch Med, Dept Mol Pharmacol & Biol Chem, Chicago, IL 60611 USA

来源：

SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY | 2011年 / 22卷 / 05期

基金：

美国国家卫生研究院;

关键词：

Prion; Yeast; Protein aggregation; Epigenetics; Amyloid; DE-NOVO APPEARANCE; SACCHAROMYCES-CEREVISIAE; PSI+ PRION; HETEROKARYON INCOMPATIBILITY; GUANIDINE-HYDROCHLORIDE; TRANSLATION TERMINATION; GENETIC-VARIATION; PROTEIN HSP104; PSI(+) PRION; URE3; PRION;

D O I：

10.1016/j.semcdb.2011.03.003

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Yeast prions are atypical genetic elements that are transmitted as heritable protein conformations. [PSI+], [URE3], and [PIN+] are three well-studied prions in the budding yeast, Saccharomyces cerevisiae. In the last three years, several additional prions have been reported in yeast, including [SWI+], [OCT+], [MCA], [GAR(+)], [MOT3(+)], [ISP+], and [NSI+]. The growing number of yeast prions suggests that protein-based inheritance might be a widespread biological phenomenon. In this review, we summarize the characteristics of each prion element, and discuss their potential functional roles in yeast biology. (C) 2011 Elsevier Ltd. All rights reserved.

引用

页码：452 / 459

页数：8

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