Effects of soluble TNF-alpha receptor 1 on apoptosis induced by oxidized LDL in endothelial cells

被引：9

作者：

Sugano, M ^{[1
]}

Tsuchida, K ^{[1
]}

Makino, N ^{[1
]}

机构：

[1] Kyushu Univ, Med Inst Bioregulat, Dept Mol & Cellular Biol, Div Mol & Clin Gerontol, Oita 8740838, Japan

来源：

MOLECULAR AND CELLULAR BIOCHEMISTRY | 2004年 / 258卷 / 1-2期

关键词：

endothelial cells; soluble TNF-alpha receptor 1; apoptosis; oxidized LDL;

D O I：

10.1023/B:MCBI.0000012836.11573.41

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Apoptosis-inducing agents have been reported to cause rapid shedding of tumor necrosis factor receptor 1 (TNFR1) in endothelial cells (EC). Oxidized LDL (oxLDL) has also been known to induce apoptosis of EC and to inhibit proliferation of EC. In the present study, we show that oxLDL also causes shedding of TNFR1 in EC and that EC transfected with soluble TNFR1 (sTNFR1), which is an extracellular domain of TNFR1, can antagonize the toxicity induced by oxLDL. These results suggest that transfection with the sTNFR1 gene plays a protective role against the injury of EC induced by oxLDL. We speculate therefore that sTNFR1 can be a new strategy for treatment of atherogenesis possibly by preventing shedding of TNFR1.

引用

页码：57 / 63

页数：7

共 29 条

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