Cytotoxic effects of flavonol glycosides and nonflavonoid constituents of Epimedium koreanum on primary osteoblasts

被引：5

作者：

Zhang, Dawei ^{[1
,2
]}

Cheng, Yan ^{[1
]}

Zhang, Jinchao ^{[3
]}

Wang, Xinluan ^{[1
,2
]}

Wang, Naili ^{[1
,2
]}

Yao, Xinsheng ^{[1
,2
]}

机构：

[1] Shenyang Pharmaceut Univ, Dept Nat Prod Chem, Shenyang 110016, Peoples R China

[2] Tradit Chinese Med & Nat Med Shenzhen, Key Lab Res & Dev, Shenzhen, India

[3] Hebei Univ, Coll Chem & Environm Sci, Dept Chem, Baoding, India

来源：

PHARMACEUTICAL BIOLOGY | 2008年 / 46卷 / 03期

基金：

中国国家自然科学基金;

关键词：

Epimedium koreanum Nakai; flavonol glycosides; nonflavonoid constituents; osteoblasts; cytotoxicity;

D O I：

10.1080/13880200701735478

中图分类号：

Q94 [植物学];

学科分类号：

071001 [植物学];

摘要：

Seven flavonol glycosides and four nonflavonoid compounds were isolated from Epimedium koreanum Nakai (Berberidaceae), and their effects on the proliferation of rat osteoblast-like (ROB) cells were evaluated with a mitochondrial activity assay. Both flavonol glycosides and nonflavonoid compounds strongly inhibited the proliferation of primary ROB cells at most concentrations (2.0 x 10(-5) mol/L similar to 1.0 x 10(-8) mol/L), and a simple structure-function relationship was also found in these compounds. Considering the antiosteoporotic effect of flavonoids in vivo, these results suggest that the flavonoids may enhance the development of osteoblasts through their active metabolites, and the mechanism between proliferation and differentiation of osteoblasts needs to be further studied to fully evaluate the mechanism of E. koreanum in the treatment of osteoporosis.

引用

页码：185 / 190

页数：6

共 25 条

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