Replication of association between ELAVL4 and Parkinson disease:: the GenePD study

被引：34

作者：

DeStefano, Anita L. ^{[1
,2
]}

Latourelle, Jeanne ^{[2
]}

Lew, Mark F. ^{[3
]}

Suchowersky, Oksana ^{[4
]}

Klein, Christine ^{[5
]}

Golbe, Lawrence I. ^{[6
]}

Mark, Margery H. ^{[6
]}

Growdon, John H. ^{[7
]}

Wooten, G. Fredrick ^{[8
]}

Watts, Ray ^{[9
]}

Guttman, Mark ^{[10
]}

Racette, Brad A. ^{[11
]}

Perlmutter, Joel S. ^{[11
]}

Marlor, Lynn ^{[12
]}

Shill, HollyA. ^{[13
]}

Singer, Carlos ^{[14
]}

Goldwurm, Stefano ^{[15
]}

Pezzoli, Gianni ^{[15
]}

Saint-Hilaire, Marie H. ^{[2
]}

Hendricks, Audrey E. ^{[1
]}

Gower, Adam ^{[16
]}

Williamson, Sally ^{[2
]}

Nagle, Michael W. ^{[2
]}

Wilk, Jemma B. ^{[2
]}

Massood, Tiffany ^{[2
]}

Huskey, Karen W. ^{[1
,2
]}

Baker, Kenneth B. ^{[17
]}

Itin, Ilia ^{[17
]}

Litvan, Irene ^{[18
]}

Nicholson, Garth ^{[19
]}

Corbett, Alastair ^{[19
]}

Nance, Martha ^{[20
]}

Drasby, Edward ^{[21
]}

Isaacson, Stuart ^{[22
]}

Burn, David J. ^{[23
]}

Chinnery, Patrick F. ^{[23
]}

Pramstaller, Peter P. ^{[24
]}

Al-hinti, Jomana ^{[25
]}

Moller, Anette T. ^{[26
]}

Ostergaard, Karen ^{[26
]}

Sherman, Scott J. ^{[27
]}

Roxburgh, Richard ^{[28
]}

Snow, Barry ^{[28
]}

Slevin, John T. ^{[29
]}

Cambi, Franca ^{[29
]}

Gusella, James F. ^{[30
]}

Myers, Richard H. ^{[2
]}

机构：

[1] Boston Univ, Sch Publ Hlth, Dept Biostat, Crosstown Ctr, Boston, MA 02118 USA

[2] Boston Univ, Sch Publ Hlth, Dept Neurol, Boston, MA 02118 USA

[3] Univ So Calif, Sch Med, Dept Neurol, Los Angeles, CA 90033 USA

[4] Univ Calgary, Dept Clin Neurosci, Calgary, AB T2N 4N1, Canada

[5] Univ Lubeck, Dept Neurol, D-23538 Lubeck, Germany

[6] Univ Med & Dent New Jersey, Robert Wood Johnson Med Sch, Dept Neurol, New Brunswick, NJ 08903 USA

[7] Massachusetts Gen Hosp, Dept Neurol, Boston, MA 02114 USA

[8] Univ Virginia Hlth Syst, Dept Neurol, Charlottesville, VA 22908 USA

[9] Univ Alabama, Dept Neurol, Birmingham, AL 35233 USA

[10] Univ Toronto, Dept Med, Toronto, ON L6B 1C9, Canada

[11] Washington Univ, Sch Med, Dept Neurol, St Louis, MO 63110 USA

[12] Barrow Neurol Inst, Phoenix, AZ 85013 USA

[13] Sun Hlth Res Inst, Sun City, AZ 85351 USA

[14] Univ Miami, Dept Neurol, Miami, FL 33136 USA

[15] Ist Clin Perfezionamento, Parkinson Inst, I-39100 Milan, Italy

[16] Boston Univ, Dept Bioinformat, Boston, MA 02215 USA

[17] Cleveland Clin Fdn, Dept Neurol & Neurosci, Cleveland, OH 44195 USA

[18] Univ Louisville, Dept Neurol, Sch Med, Louisville, KY 40202 USA

[19] Univ Sydney, Concord Hosp, Dept Neurol, ANZAC Res Inst, Sydney, NSW 2006, Australia

[20] Struthers Parkinsons Ctr, Minneapolis, MN 55427 USA

[21] Port City Neurol, Scarborough, ME 04074 USA

[22] Parkinsons Dis & Movement Disorder Ctr Boca Raton, Boca Raton, FL 33486 USA

[23] Univ Newcastle, Inst Ageing & Hlth, Reg Neurosci Ctr, Newcastle Upon Tyne NE4 6BE, Tyne & Wear, England

[24] Gen Reg Hosp Bolzano, Dept Neurol, I-39100 Bolzano, Italy

[25] Univ Arkansas Med Sci, Dept Neurol, Little Rock, AR 72205 USA

[26] Aarhus Univ Hosp, Dept Neurol, Aarhus 8000, Denmark

[27] Univ Arizona, Dept Neurol, Tucson, AZ 85724 USA

[28] Auckland City Hosp, Dept Neurol, Auckland, New Zealand

[29] Univ Kentucky, Coll Med, Dept Neurol, Lexington, KY 40536 USA

[30] Harvard Univ, Massachusetts Gen Hosp, Sch Med, Mol Neurogenet Unit,Ctr Human Genet Res, Boston, MA 02114 USA

来源：

HUMAN GENETICS | 2008年 / 124卷 / 01期

关键词：

D O I：

10.1007/s00439-008-0526-4

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

Genetic variants in embryonic lethal, abnormal vision, Drosophila-like 4 (ELAVL4) have been reported to be associated with onset age of Parkinson disease (PD) or risk for PD affection in Caucasian populations. In the current study we genotyped three single nucleotide polymorphisms in ELAVL4 in a Caucasian study sample consisting of 712 PD patients and 312 unrelated controls from the GenePD study. The minor allele of rs967582 was associated with increased risk of PD (odds ratio = 1.46, nominal P value = 0.011) in the GenePD population. The minor allele of rs967582 was also the risk allele for PD affection or earlier onset age in the previously studied populations. This replication of association with rs967582 in a third cohort further implicates ELAVL4 as a PD susceptibility gene.

引用

页码：95 / 99

页数：5

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