A new fluorescent chemosensor for copper ions based on tripeptide glycyl-histidyl-lysine (GHK)

被引：135

作者：

Zheng, YJ

Huo, Q

Kele, P

Andreopoulos, FM

Pham, SM

Leblanc, RM

机构：

[1] Univ Miami, Ctr Supramol Sci, Coral Gables, FL 33124 USA

[2] Univ Miami, Dept Chem, Coral Gables, FL 33124 USA

[3] Univ Miami, Dept Surg, Miami, FL 33136 USA

[4] Univ Miami, Sch Med, Dept Biomed Engn, Miami, FL 33136 USA

来源：

ORGANIC LETTERS | 2001年 / 3卷 / 21期

关键词：

D O I：

10.1021/ol0101638

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

[GRAPHICS] A new fluorescent chemosensor for Cu2+ ions was synthesized by modifying the tripeptide glycyl-histidyl-lysine (GHK) with 9-carbonylanthracene via the standard Fmoc solid-phase peptide synthesis method. While significant fluorescence quenching was observed from the molecule upon binding with Cu2+, addition of Fe2+, Co2+, Ni2+, and Zn2+ to the peptide solution caused a minimum fluorescence emission spectral change, indicating a high specificity of this chemosensor for Cu2+ ions. Effects of pH were also investigated.

引用

页码：3277 / 3280

页数：4

共 28 条

[1]

ALETRAS A, 1995, INT J PEPT PROT RES, V45, P488

[2]

[Anonymous], 1994, TOPICS FLUORESCENCE

[3] CYCLOBIS(PARAQUAT-P-PHENYLENE) AS A SYNTHETIC RECEPTOR FOR ELECTRON-RICH AROMATIC-COMPOUNDS - ELECTROCHEMICAL AND SPECTROSCOPIC STUDIES OF NEUROTRANSMITTER BINDING [J].