Radiofungicidal effects of external gamma radiation and antibody-targeted beta and alpha radiation on Cryptococcus neoformans

被引：17

作者：

Bryan, Ruth A. ^{[3
]}

Huang, Xianchun ^{[3
]}

Morgenstern, Alfred

Bruchertseifer, Frank

Casadevall, Arturo ^{[1
,2
]}

Dadachova, Ekaterina ^{[1
,3
]}

机构：

[1] Albert Einstein Coll Med, Dept Microbiol & Immunol, Bronx, NY 10461 USA

[2] Albert Einstein Coll Med, Dept Med, Bronx, NY 10461 USA

[3] Commiss European Communities, Joint Res Ctr, Inst Transuranium Elements, Dept Nucl Med, D-7500 Karlsruhe, Germany

来源：

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY | 2008年 / 52卷 / 06期

关键词：

D O I：

10.1128/AAC.01245-07

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

We evaluated the clonogenic survival, membrane permeability, metabolic activity (XTT reduction), and apoptosis (FLICA binding) of Cryptococcus neoformans cells subjected to gamma rays from an external source, and beta and alpha particles delivered to fungal cells by capsule-specific antibody. We found that gamma, beta, and alpha radiation affected cells through different pathways.

引用

页码：2232 / 2235

页数：4

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