The many roles of TOX in the immune system

被引：102

作者：

Aliahmad, Parinaz ^{[1
]}

Seksenyan, Akop ^{[1
]}

Kaye, Jonathan ^{[1
,2
]}

机构：

[1] Cedars Sinai Med Ctr, Div Immunol Res, Dept Biomed Sci, Dept Med,Samuel Oschin Comprehens Canc Inst, Los Angeles, CA 90048 USA

[2] Univ Calif Los Angeles, David Geffen Sch Med, Dept Med, Los Angeles, CA 90095 USA

来源：

CURRENT OPINION IN IMMUNOLOGY | 2012年 / 24卷 / 02期

关键词：

T-CELL DEVELOPMENT; HELIX INHIBITOR ID2; TRANSCRIPTION FACTORS; LYMPHOCYTE DEVELOPMENT; LINEAGE COMMITMENT; BREAST-CANCER; B-CELL; THPOK; RUNX; THYMOCYTES;

D O I：

10.1016/j.coi.2011.12.001

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

071005 [微生物学]; 100108 [医学免疫学];

摘要：

TOX is a member of an evolutionarily conserved DNA-binding protein family and is expressed in several immune-relevant cell subsets. Here, we review the key role of TOX in regulating development of CD4 T cells, natural killer cells and lymphoid tissue inducer cells, the latter responsible for the generation of lymph nodes. Although the exact molecular mechanism of action of TOX remains to be elucidated, the role of TOX in establishment of gene programs in the thymus and the potential of TOX as a regulator of E protein activity are discussed.

引用

收藏

页码：173 / 177

页数：5

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