Entry into a new class of protein kinase inhibitors by pseudo ring design

被引：56

作者：

Furet, Pascal ^{[1
]}

Caravatti, Giorgio ^{[1
]}

Guagnano, Vito ^{[1
]}

Lang, Marc ^{[1
]}

Meyer, Thomas ^{[1
]}

Schoepfer, Joseph ^{[1
]}

机构：

[1] Novartis Inst BioMed Res, CH-4002 Basel, Switzerland

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 2008年 / 18卷 / 03期

关键词：

kinase; scaffold morphing; pseudo ring;

D O I：

10.1016/j.bmcl.2007.12.041

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

A pyrimidin-4-yl-urea motif forming a pseudo ring by intramolecular hydrogen bonding has been designed to mimic the pyrido[2,3-d]pyrimidin-7-one core structure of a well-established class of protein kinase inhibitors. Potent inhibition of a number of protein kinases was obtained with the first prototype compound synthesized to probe the design concept. (C) 2007 Elsevier Ltd. All rights reserved.

引用

页码：897 / 900

页数：4

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