The initiating proteases of the complement system: Controlling the cleavage

被引：24

作者：

Duncan, Renee C. ^{[1
]}

Wijeyewickrema, Lakshmi C. ^{[1
]}

Pike, Robert N. ^{[1
]}

机构：

[1] Monash Univ, Dept Biochem & Mol Biol, Clayton, Vic 3800, Australia

来源：

BIOCHIMIE | 2008年 / 90卷 / 02期

关键词：

complement system; Cls; Clr; MASP-2; protease; serpin; C1-inhibitor;

D O I：

10.1016/j.biochi.2007.07.023

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The complement system is a vital component of the host immune system, but when dysregulated, can also cause disease. The system is activated by three pathways: classical, lectin and alternative. The initiating proteases of the classical and lectin pathways have similar domain structure and employ similar mechanisms of activation. The Clr, Cls and MASP-2 proteases have the most defined roles in the activation of the system. This review focuses on the mechanisms whereby their interaction with substrates and inhibitors is regulated. (c) 2007 Elsevier Masson SAS. All rights reserved.

引用

页码：387 / 395

页数：9

共 73 条

[1]

[Anonymous], IMMUNOBIOLOGY IMMUNE

[2] Structure, function and molecular genetics of human and murine C1r [J].

Arlaud, GJ ;

Gaboriaud, C ;

Garnier, G ;

Circolo, A ;

Thielens, NM ;

Budayova-Spano, M ;

Fontecilla-Camps, JC ;

Volanakis, JE .

IMMUNOBIOLOGY, 2002, 205 (4-5) :365-382

[3] Structural biology of C1: dissection of a complex molecular machinery [J].

Arlaud, GJ ;

Gaboriaud, C ;

Thielens, NM ;

Rossi, V ;

Bersch, B ;

Hernandez, JF ;

Fontecilla-Camps, JC .

IMMUNOLOGICAL REVIEWS, 2001, 180 :136-145

[4] Crystal structures of native and thrombin-complexed heparin cofactor II reveal a multistep allosteric mechanism [J].

Baglin, TP ;

Carrell, RW ;

Church, FC ;

Esmon, CT ;

Huntington, JA .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2002, 99 (17) :11079-11084

[5] C1 inhibitor serpin domain structure reveals the likely mechanism of heparin potentiation and conformational disease [J].

Beinrohr, Laszlo ;

Harmat, Veronika ;

Dobo, Jozsef ;

Loerincz, Zsolt ;

Gal, Peter ;

Zavodszky, Peter .

JOURNAL OF BIOLOGICAL CHEMISTRY, 2007, 282 (29) :21100-21109

[6] HUMAN C1BAR INHIBITOR - PRIMARY STRUCTURE, CDNA CLONING, AND CHROMOSOMAL LOCALIZATION [J].

BOCK, SC ;

SKRIVER, K ;

NIELSEN, E ;

THOGERSEN, HC ;

WIMAN, B ;

DONALDSON, VH ;

EDDY, RL ;

MARRINAN, J ;

RADZIEJEWSKA, E ;

HUBER, R ;

SHOWS, TB ;

MAGNUSSON, S .

BIOCHEMISTRY, 1986, 25 (15) :4292-4301

[7] THE CUB DOMAIN - A WIDESPREAD MODULE IN DEVELOPMENTALLY-REGULATED PROTEINS [J].

BORK, P ;

BECKMANN, G .

JOURNAL OF MOLECULAR BIOLOGY, 1993, 231 (02) :539-545

[8] C1q, autoimmunity and apoptosis [J].

Botto, M ;

Walport, MJ .

IMMUNOBIOLOGY, 2002, 205 (4-5) :395-406

[9] Monomeric structures of the zymogen and active catalytic domain of complement protease C1r: Further insights into the C1 activation mechanism [J].

Budayova-Spano, M ;

Grabarse, W ;

Thielens, NM ;

Hillen, H ;

Lacroix, M ;

Schmidt, M ;

Fontecilla-Camps, JC ;

Arlaud, GJ ;

Gaboriaud, C .

STRUCTURE, 2002, 10 (11) :1509-1519

[10] NH2-TERMINAL CALCIUM-BINDING DOMAIN OF HUMAN-COMPLEMENT CL-BARS MEDIATES THE INTERACTION OF CL-BARR WITH CLQ [J].

BUSBY, TF ;

INGHAM, KC .

BIOCHEMISTRY, 1990, 29 (19) :4613-4618

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