The expression of vascular endothelial growth factor C and its receptors in non-small cell lung cancer

被引:142
作者
Kajita, T
Ohta, Y
Kimura, K
Tamura, M
Tanaka, Y
Tsunezuka, Y
Oda, M
Sasaki, T
Watanabe, G
机构
[1] Kanazawa Univ, Sch Med, Dept Surg 1, Kanazawa, Ishikawa 9208641, Japan
[2] Kanazawa Univ, Inst Canc Res, Dept Expt Therapeut, Kanazawa, Ishikawa 9208641, Japan
关键词
VEGF-C; lung cancer; lymph node metastasis; VEGFR;
D O I
10.1054/bjoc.2001.1882
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
Expression of vascular endothelial growth factor (VEGF)-C and that of its receptors were assessed in non-small cell lung cancer. Immunohistochemistry revealed positive VEGF-C expression in 38.7% (24/62) of the patients studied. A significant positive correlation was found between VEGF-C in cancer cells and VEGF receptor-3 (VEGFR-3) in vascular endothelial cells, but not between VEGF-C in cancer cells and VEGFR-2 in endothelial cells. In this cohort of lung cancer patients, VEGF-C expression was significantly associated with lymph node metastasis, lymphatic vessel invasion, and worse outcomes after the operation. Although the independent prognostic impact of VEGF-C and VEGFR-3 was not clear, VEGFR-2 expression in endothelial cells retained the independency as the prognostic indicator. In light of these findings, we conclude that VEGF-C plays an important role in lymphatic invasion/metastasis and tumour progression in non-small cell lung cancer. (C) 2001 Cancer Research Campaign.
引用
收藏
页码:255 / 260
页数:6
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