Cancer genetics: Tumor suppressor meets oncogene

被引：30

作者：

Fearon, ER ^{[1
]}

Dang, CV

机构：

[1] Univ Michigan, Ctr Canc, Dept Internal Med, Div Med & Mol Genet, Ann Arbor, MI 48109 USA

[2] Univ Michigan, Ctr Canc, Dept Human Genet, Ann Arbor, MI 48109 USA

[3] Univ Michigan, Ctr Canc, Dept Pathol, Ann Arbor, MI 48109 USA

[4] Johns Hopkins Univ, Sch Med, Dept Med, Div Hematol, Baltimore, MD 21205 USA

[5] Johns Hopkins Univ, Sch Med, Dept Oncol, Program Mol Med, Baltimore, MD 21205 USA

来源：

CURRENT BIOLOGY | 1999年 / 9卷 / 02期

关键词：

D O I：

10.1016/S0960-9822(99)80012-8

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The adenomatous polyposis coli (APC) tumor suppressor protein is inactivated by mutations in the majority of colorectal cancers. A recent study has revealed that alterations in the APC signaling pathway can result in the transcriptional activation of the c-MYC gene.

引用

页码：R62 / R65

页数：4

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