Abietane diterpenes from the cones of Cedrus atlantica

被引：25

作者：

Barrero, AF

del Moral, JFQ

Herrador, MM

Arteaga, JF

Akssira, M

Benharref, A

Dakir, M

机构：

[1] Univ Granada, Fac Ciencias, Dept Quim Organ, Inst Biotecnol, E-18071 Granada, Spain

[2] Univ Hassan II Mohammedia, Chim Bioorgan & Analyt Lab, FST, Mohammadia 20800, Morocco

[3] Fac Sci, Lab Chim Subst Nat & Heterocycles, Marrakech, Morocco

来源：

PHYTOCHEMISTRY | 2005年 / 66卷 / 01期

关键词：

Cedrus atlantica; pinaceae; diterpenoids; abietanes;

D O I：

10.1016/j.phytochem.2004.10.017

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Five abietanes, three of them isolated as the corresponding acetate derivatives, i.e., 9alpha,13alpha-epidioxiabiet-8(14)-en-18-ol, 7alpha,18-diacetoxy, 9beta,13beta-epidioxiabiet-8(14)-ene, 7alpha,18-diacetoxyabiet-8(14)-en-13beta-ol, 7alpha,18-diacetoxy-13beta-methoxyabiet-8(14)-ene, and 13beta-hydroxyabiet-8(14)-en-7-one, were isolated from the neutral part of the hexane extract of the cones of Cedrus atlantica collected in Middle Atlas, Morocco. The structures of these compounds were established by spectroscopic techniques, including 2D NMR spectra, and in the case of 1, by chemical correlation. The cytotoxicity of these abietane diterpenoids was tested against five cell lines. (C) 2004 Elsevier Ltd. All rights reserved.

引用

页码：105 / 111

页数：7

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