Simultaneous determination of dopamine and serotonin on a glassy carbon electrode coated with a film of carbon nanotubes

被引：323

作者：

Wu, KB ^{[1
]}

Fei, JJ ^{[1
]}

Hu, SS ^{[1
]}

机构：

[1] Wuhan Univ, Dept Chem, Wuhan 430072, Peoples R China

来源：

ANALYTICAL BIOCHEMISTRY | 2003年 / 318卷 / 01期

基金：

中国国家自然科学基金;

关键词：

carbon nanotubes; dopamine; serotonin; modified electrode;

D O I：

10.1016/S0003-2697(03)00174-X

中图分类号：

Q5 [生物化学];

学科分类号：

071010 ; 081704 ;

摘要：

A chemically modified electrode based on the carbon nanotube film-coated glassy carbon electrode (GCE) is described for the simultaneous determination of dopamine (DA) and serotonin (5-HT). The multiwall carbon nanotube (MWNT) film-coated GCE exhibits a marked enhancement effect on the current response of DA and 5-HT and lowers oxidation overpotentials. The responses of DA and 5-HT merge into a large peak at a bare GCE, but they yield two well-defined oxidation peaks at the MWNT film-coated GCE. The experimental parameters were optimized, and a direct electrochemical method for the simultaneous determination of DA and 5-HT was proposed. The interference of ascorbic acid (AA) was investigated, and the results showed that a large excess of AA did not interfere with the voltammetric responses of DA and 5-HT. The modified electrode has been successfully applied for the assay of 5-HT and DA in human blood serum. (C) 2003 Elsevier Science (USA). All rights reserved.

引用

页码：100 / 106

页数：7

共 35 条

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