Vitamin E inhibition of platelet aggregation is independent of antioxidant activity

被引:62
作者
Freedman, JE [1 ]
Keaney, JF
机构
[1] Boston Univ, Sch Med, Whitaker Cardiovasc Inst, Boston, MA 02118 USA
[2] Boston Univ, Sch Med, Evans Dept Med, Boston, MA 02118 USA
[3] Georgetown Univ, Med Ctr, Dept Pharmacol, Washington, DC 20007 USA
[4] Georgetown Univ, Med Ctr, Dept Med, Washington, DC 20007 USA
关键词
vitamins; antioxidants; platelets; platelet aggregation inhibitors; thrombosis;
D O I
10.1093/jn/131.2.374S
中图分类号
R15 [营养卫生、食品卫生]; TS201 [基础科学];
学科分类号
100403 ;
摘要
Vitamin E is the principal lipid-soluble antioxidant in human plasma, and some studies indicate that it may provide cardiovascular protection. To investigate putative mechanisms for vitamin E in this regard, the effect of vitamin E on vascular function and platelet aggregation was examined. In animal models of endothelial dysfunction, vitamin E improved the activity of endothelium-derived nitric oxide, and this effect was not dependent upon the antioxidant protection of LDL. In fact, vitamin E improved endothelial function in part due to the inhibition of protein kinase C (PKC) stimulation. This activity of vitamin E was examined in platelets, and vitamin E inhibited platelet aggregation in part through a mechanism that involves PKC, Moreover, the platelet inhibitory activity of vitamin E was independent of its antioxidant action because platelet inhibition was still observed with isoforms of vitamin E that were devoid of antioxidant activity.
引用
收藏
页码:374S / 377S
页数:4
相关论文
共 14 条
[1]   ALPHA-TOCOPHEROL (VITAMIN-E) REGULATES VASCULAR SMOOTH-MUSCLE CELL-PROLIFERATION AND PROTEIN-KINASE-C ACTIVITY [J].
BOSCOBOINIK, D ;
SZEWCZYK, A ;
AZZI, A .
ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS, 1991, 286 (01) :264-269
[2]  
Budavari S., 2000, MERCK INDEX
[3]   Mechanisms of disease - Antioxidants and atherosclerotic heart disease [J].
Diaz, MN ;
Frei, B ;
Vita, JA ;
Keaney, JF .
NEW ENGLAND JOURNAL OF MEDICINE, 1997, 337 (06) :408-416
[4]  
Duffy S, 1999, HEART FAILURE, V15, P135
[5]   alpha-tocopherol inhibits aggregation of human platelets by a protein kinase C-dependent mechanism [J].
Freedman, JE ;
Farhat, JH ;
Loscalzo, J ;
Keaney, JF .
CIRCULATION, 1996, 94 (10) :2434-2440
[6]  
HEINONEN OP, 1994, NEW ENGL J MED, V330, P1029
[7]   Vascular incorporation of alpha-tocopherol prevents endothelial dysfunction due to oxidized LDL by inhibiting protein kinase C stimulation [J].
Keaney, JF ;
Guo, Y ;
Cunningham, D ;
Shwaery, GT ;
Xu, AM ;
Vita, JA .
JOURNAL OF CLINICAL INVESTIGATION, 1996, 98 (02) :386-394
[8]   MOLECULAR-BASES OF THE ACUTE CORONARY SYNDROMES [J].
LIBBY, P .
CIRCULATION, 1995, 91 (11) :2844-2850
[9]   α-Tocopherol specifically inactivates cellular protein kinase C α by changing its phosphorylation state [J].
Ricciarelli, R ;
Tasinato, A ;
Clément, S ;
Özer, NK ;
Boscoboinik, D ;
Azzi, A .
BIOCHEMICAL JOURNAL, 1998, 334 :243-249
[10]  
Shwaery GT, 1997, CIRCULATION, V95, P1378