On the existence of cellular tocopheryl phosphate, its synthesis, degradation and cellular roles: A hypothesis

被引：42

作者：

Negis, Y

Zingg, JM

Ogru, E

Gianello, R

Libinaki, R

Azzi, A

机构：

[1] Univ Bern, Inst Biochem & Mol Biol, CH-3012 Bern, Switzerland

[2] Marmara Univ, Dept Biochem, Istanbul, Turkey

[3] Phosphagen Ltd, Melbourne, Vic 3000, Australia

[4] Monash Univ, Dept Biochem, Clayton, Vic 3168, Australia

来源：

IUBMB LIFE | 2005年 / 57卷 / 01期

关键词：

alpha-tocopherol; vitamin E; tocopherol esters; alpha-tocopheryl phosphate; cell signaling;

D O I：

10.1080/15216540500058980

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The finding that alpha-tocopheryl phosphate is present in cells in small amounts, that it can be synthesized and hydrolyzed supports the hypothesis that alpha-tocopheryl phosphate might be a signaling molecule. The possible pathways needed for the synthesis, hydrolysis and signaling are considered in this hypothesis as well the possible extension of this reaction to additional molecules such as tocopherols and tocotrienols. A possible mechanism of action of other tocopherol esters ( succinate and maleate) is also hypothesized.

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收藏

页码：23 / 25

页数：3

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