Adenosine and the nervous system: Pharmacological data and therapeutic perspectives

被引：25

作者：

Guieu, R

Dussol, B

Halimi, G

Bechis, G

Sampieri, F

Berland, Y

Sampol, J

Couraud, F

Rochat, H

机构：

[1] Fac Med Sect Nord, URA CNRS 1455, Lab Biochim & Ingn Prot, F-13015 Marseille, France

[2] Hop St Marguerite, Ctr Invest Clin, F-13009 Marseille, France

[3] Fac Med Sect Nord, INSERM U374, F-13015 Marseille, France

来源：

GENERAL PHARMACOLOGY-THE VASCULAR SYSTEM | 1998年 / 31卷 / 04期

关键词：

adenosine; nervous system; therapeutic;

D O I：

10.1016/S0306-3623(98)00071-8

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

1. Adenosine acts on a family of G-protein-coupled receptors called purinoreceptors. 2, Four subtypes have been cloned and pharmacologically characterized. 3. The principal pharmacological data and structure-function relations for agonist interactions with P1 receptors are presented. 4. We conclude that the potent role of adenosine in the nervous system may be interesting for the development of drugs targeted at purines and their receptors. (C) 1998 Elsevier Science Inc.

引用

页码：553 / 561

页数：9

共 161 条

[1] ADENOSINE MODULATES THE DOPAMINERGIC FUNCTION IN THE NIGRO-STRIATAL SYSTEM BY INTERACTING WITH STRIATAL DOPAMINE DEPENDENT ADENYLATE-CYCLASE [J].