Comparison of Pandemic (H1N1) 2009 and Seasonal Influenza Viral Loads, Singapore

被引:26
作者
Lee, Chun K. [4 ]
Lee, Hong K.
Loh, Tze P.
Lai, Florence Y. L. [2 ]
Tambyah, Paul A. [3 ]
Chiu, Lily
Koay, Evelyn S. C. [3 ]
Tang, Julian W. [1 ]
机构
[1] Natl Univ Singapore Hosp, Dept Lab Med, Singapore 119074, Singapore
[2] Minist Hlth, Singapore, Singapore
[3] Natl Univ Singapore, Singapore 117548, Singapore
[4] Natl Univ Singapore Hosp, Mol Diag Ctr, Singapore 119074, Singapore
关键词
VIRUS; INFECTIONS;
D O I
10.3201/eid1702.100282
中图分类号
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号
100102 ;
摘要
Mean viral loads for patients with pandemic (H1N1) 2009 were approximate to 1 log(10) times lower than those for patients with seasonal influenza within the first week after symptom on-set. Neither pandemic nor seasonal influenza viral loads correlated with clinical severity of illness. No correlation was found between viral loads and concurrent illness.
引用
收藏
页码:287 / 291
页数:5
相关论文
共 14 条
[1]   Host adaptive immunity deficiency in severe pandemic influenza [J].
Bermejo-Martin, Jesus F. ;
Martin-Loeches, Ignacio ;
Rello, Jordi ;
Anton, Andres ;
Almansa, Raquel ;
Xu, Luoling ;
Lopez-Campos, Guillermo ;
Pumarola, Tomas ;
Ran, Longsi ;
Ramirez, Paula ;
Banner, David ;
Ng, Derek Cheuk ;
Socias, Lorenzo ;
Loza, Ana ;
Andaluz, David ;
Maravi, Enrique ;
Gomez-Sanchez, Maria J. ;
Gordon, Monica ;
Gallegos, Maria C. ;
Fernandez, Victoria ;
Aldunate, Sara ;
Leon, Cristobal ;
Merino, Pedro ;
Blanco, Jesus ;
Martin-Sanchez, Fernando ;
Rico, Lucia ;
Varillas, David ;
Iglesias, Veronica ;
Angeles Marcos, Maria ;
Gandia, Francisco ;
Bobillo, Felipe ;
Nogueira, Begona ;
Rojo, Silvia ;
Resino, Salvador ;
Castro, Carmen ;
Ortiz de Lejarazu, Raul ;
Kelvin, David .
CRITICAL CARE, 2010, 14 (05)
[2]   Th1 and Th17 hypercytokinemia as early host response signature in severe pandemic influenza [J].
Bermejo-Martin, Jesus F. ;
Ortiz de Lejarazu, Raul ;
Pumarola, Tomas ;
Rello, Jordi ;
Almansa, Raquel ;
Ramirez, Paula ;
Martin-Loeches, Ignacio ;
Varillas, David ;
Gallegos, Maria C. ;
Seron, Carlos ;
Micheloud, Dariela ;
Manuel Gomez, Jose ;
Tenorio-Abreu, Alberto ;
Ramos, Maria J. ;
Lourdes Molina, M. ;
Huidobro, Samantha ;
Sanchez, Elia ;
Gordon, Monica ;
Fernandez, Victoria ;
del Castillo, Alberto ;
Angeles Marcos, Ma ;
Villanueva, Beatriz ;
Javier Lopez, Carlos ;
Rodriguez-Dominguez, Mario ;
Galan, Juan-Carlos ;
Canton, Rafael ;
Lietor, Aurora ;
Rojo, Silvia ;
Eiros, Jose M. ;
Hinojosa, Carmen ;
Gonzalez, Isabel ;
Torner, Nuria ;
Banner, David ;
Leon, Alberto ;
Cuesta, Pablo ;
Rowe, Thomas ;
Kelvin, David J. .
CRITICAL CARE, 2009, 13 (06)
[3]   Transmission of influenza: Implications for control in health care settings [J].
Bridges, CB ;
Kuehnert, MJ ;
Hall, CB .
CLINICAL INFECTIOUS DISEASES, 2003, 37 (08) :1094-1101
[4]   Serologic Survey of Pandemic (H1N1) 2009 Virus, Guangxi Province, China [J].
Chen, Honglin ;
Wang, Yong ;
Liu, Wei ;
Zhang, Jinxia ;
Dong, Baiqing ;
Fan, Xiaohui ;
de Jong, Menno D. ;
Farrar, Jeremy ;
Riley, Steven ;
Smith, Gavin J. D. ;
Guan, Yi .
EMERGING INFECTIOUS DISEASES, 2009, 15 (11) :1849-1850
[5]   Emergence of a Novel Swine-Origin Influenza A (H1N1) Virus in Humans Novel Swine-Origin Influenza A (H1N1) Virus Investigation Team [J].
Dawood, Fatimah S. ;
Jain, Seema ;
Finelli, Lyn ;
Shaw, Michael W. ;
Lindstrom, Stephen ;
Garten, Rebecca J. ;
Gubareva, Larisa V. ;
Xu, Xiyan ;
Bridges, Carolyn B. ;
Uyeki, Timothy M. .
NEW ENGLAND JOURNAL OF MEDICINE, 2009, 360 (25) :2605-2615
[6]  
Gill JR, 2010, ARCH PATHOL LAB MED, V134, P235, DOI 10.5858/134.2.235
[7]   Cross-Reactive Antibody Responses to the 2009 Pandemic H1N1 Influenza Virus. [J].
Hancock, Kathy ;
Veguilla, Vic ;
Lu, Xiuhua ;
Zhong, Weimin ;
Butler, Ebonee N. ;
Sun, Hong ;
Liu, Feng ;
Dong, Libo ;
DeVos, Joshua R. ;
Gargiullo, Paul M. ;
Brammer, T. Lynnette ;
Cox, Nancy J. ;
Tumpey, Terrence M. ;
Katz, Jacqueline M. .
NEW ENGLAND JOURNAL OF MEDICINE, 2009, 361 (20) :1945-1952
[8]   Aberrant innate immune response in lethal infection of macaques with the 1918 influenza virus [J].
Kobasa, Darwyn ;
Jones, Steven M. ;
Shinya, Kyoko ;
Kash, John C. ;
Copps, John ;
Ebihara, Hideki ;
Hatta, Yasuko ;
Kim, Jin Hyun ;
Halfmann, Peter ;
Hatta, Masato ;
Feldmann, Friederike ;
Alimonti, Judie B. ;
Fernando, Lisa ;
Li, Yan ;
Katze, Michael G. ;
Feldmann, Heinz ;
Kawaoka, Yoshihiro .
NATURE, 2007, 445 (7125) :319-323
[9]   Diagnostic Testing for Pandemic Influenza in Singapore A Novel Dual-Gene Quantitative Real-Time RT-PCR for the Detection of Influenza A/H1N1/2009 [J].
Lee, Hong Kai ;
Lee, Chun Kiat ;
Loh, Tze Ping ;
Tang, Julian Wei-Tze ;
Chiu, Lily ;
Tambyah, Paul A. ;
Sethi, Sunil K. ;
Koay, Evelyn Siew-Chuan .
JOURNAL OF MOLECULAR DIAGNOSTICS, 2010, 12 (05) :636-643
[10]   Innate immune responses to influenza A H5N1: friend or foe? [J].
Peiris, Joseph Sriyal Malik ;
Cheung, Chung Yan ;
Leung, Connie Yin Hung ;
Nicholls, John Malcolm .
TRENDS IN IMMUNOLOGY, 2009, 30 (12) :574-584