In vitro synergistic effects of some novel Cu(II) complexes in combination with epirubicin and mitomycin C against HeLa-S3 cervical cancer cell line

被引：7

作者：

Geromichalos, GD ^{[1
]}

Katsoulos, GA ^{[1
]}

Hadjikostas, CC ^{[1
]}

Kortsaris, AH ^{[1
]}

Kyriakidis, DA ^{[1
]}

机构：

[1] ARISTOTELIAN UNIV THESSALONIKI, DEPT CHEM, GR-54006 THESSALONIKI, GREECE

来源：

ANTI-CANCER DRUGS | 1996年 / 7卷 / 04期

关键词：

Cu(II) complexes; cytotoxicity assay; epirubicin; HeLa-S3; cells; mitomycin C; synergism; XTT tetrazolium salt;

D O I：

10.1097/00001813-199606000-00012

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

The in vitro predictive chemosensitivity of a HeLa-S3 human cervical cancer cell line to a new series of Cu(ll) complexes as well as their combination with several chemotherapeutic drugs was determined. Antiproliferative activity was evaluated by the XTT assay, Among all tested drugs, HeLa-S3 cells were especially sensitive to epirubicin (EPR) or mitomycin C (MMC) antitumor agents, The combination of EPR or MMC with the complexes resulted in a pronounced synergistic amplification of their antiproliferative effect, This marked synergism was observed in all drug combinations.

引用

页码：469 / 475

页数：7

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