Dynamic organization of lymphocyte plasma membrane: lessons from advanced imaging methods

被引：27

作者：

Owen, Dylan M. ^{[2
]}

Gaus, Katharina ^{[2
]}

Magee, Anthony I. ^{[1
]}

Cebecauer, Marek ^{[1
]}

机构：

[1] Univ London Imperial Coll Sci Technol & Med, Natl Heart & Lung Inst, London SW7 2AZ, England

[2] Univ New S Wales, Ctr Vasc Res, Sydney, NSW, Australia

来源：

IMMUNOLOGY | 2010年 / 131卷 / 01期

基金：

英国医学研究理事会;

关键词：

lipid rafts; membrane domains; live cell imaging; lymphocytes; advanced imaging; FLUORESCENCE CORRELATION SPECTROSCOPY; FLUID/FLUID PHASE-SEPARATION; SINGLE-MOLECULE TRACKING; FC-EPSILON-RI; LIPID RAFTS; STIMULATED-EMISSION; SIGNAL INITIATION; DIFFUSION; PROTEINS; DOMAINS;

D O I：

10.1111/j.1365-2567.2010.03319.x

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

P>Lipids and lipid domains are suggested to play an essential role in the heterogeneous organization of the plasma membrane in eukaryotic cells, including cells of the immune system. We summarize the results of advanced imaging and physical studies of membrane organization with special focus on the plasma membrane of lymphocytes. We provide a comprehensive up-to-date view on the existence of membrane lipid and protein clusters such as lipid rafts and suggest research directions to better understand these highly dynamic entities on the surface of immune cells.

引用

页码：1 / 8

页数：8

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