New highlights on stroma-epithelial interactions in breast cancer

被引：64

作者：

Barcellos-Hoff, MH ^{[1
]}

Medina, D

机构：

[1] Univ Calif Berkeley, Lawrence Berkeley Lab, Div Life Sci, Berkeley, CA 94720 USA

[2] Baylor Sch Med, Dept Mol & Cellular Biol, Houston, TX USA

来源：

BREAST CANCER RESEARCH | 2005年 / 7卷 / 01期

关键词：

breast; carcinogenesis; chemical carcinogen; radiation; stroma; transforming growth factor beta 1;

D O I：

10.1186/bcr972

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Although the stroma in which carcinomas arise has been previously regarded as a bystander to the clonal expansion and acquisition of malignant characteristics of tumor cells, it is now generally acknowledged that stromal changes are required for the establishment of cancer. In the present article, we discuss three recent publications that highlight the complex role the stroma has during the development of cancer and the potential for targeting the stroma by therapeutic approaches.

引用

页码：33 / 36

页数：4

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