Selective estrogen receptor modulators (SERMs): A review of clinical data

被引：90

作者：

Mirkin, Sebastian ^{[1
]}

Pickar, James H. ^{[2
]}

机构：

[1] TherapeuticsMD, Boca Raton, FL USA

[2] Columbia Univ, Med Ctr, New York, NY USA

来源：

MATURITAS | 2015年 / 80卷 / 01期

关键词：

SERM; Menopause; Breast cancer; Osteoporosis; Endometrial cancer; SURGICAL ADJUVANT BREAST; POSTMENOPAUSAL WOMEN; BOWEL PROJECT; CARDIOVASCULAR EVENTS; ENDOMETRIAL CANCER; RISK REDUCTION; DOUBLE-BLIND; FOLLOW-UP; TAMOXIFEN; RALOXIFENE;

D O I：

10.1016/j.maturitas.2014.10.010

中图分类号：

R592 [老年病学]; C [社会科学总论];

学科分类号：

030301 [社会学]; 100201 [内科学];

摘要：

SERMs represent a diverse group of molecules with varying levels of estrogenic agonist and antagonist activity in target tissues. SERMs have a long regulatory approval history and have been studied for a variety of therapeutic indications. The clinical effects of SERMs have been evaluated in a large number of phase 3 clinical trials. Many of the available SERMs have proved to be effective as chemo-preventive agents and treatments for breast cancer and a number are useful for the prevention and treatment of osteoporosis. The endometrial effect of SERMs has been a key differentiator in clinical practice and a major hurdle for regulatory approval. The effect of SERMs in the vagina also represents a major distinction among different SERMs. This review summarized key clinical finding of SERMs in different target tissues. (C) 2014 Elsevier Ireland Ltd. All rights reserved.

引用

页码：52 / 57

页数：6

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