Growing literature but limited evidence: A systematic review regarding prebiotic and probiotic interventions for those with traumatic brain injury and/or posttraumatic stress disorder

被引:54
作者
Brenner, Lisa A. [1 ,2 ,3 ,4 ]
Stearns-Yoder, Kelly A. [1 ,4 ]
Hoffberg, Adam S. [1 ]
Penzenik, Molly E. [1 ]
Starosta, Amy J. [1 ]
Hernandez, Theresa D. [1 ,2 ,5 ,6 ]
Hadidi, Daniel A. [1 ,2 ,6 ]
Lowry, Christopher A. [1 ,2 ,4 ,6 ,7 ,8 ]
机构
[1] Rocky Mt Mental Illness Res Educ & Clin Ctr MIREC, Denver, CO USA
[2] Univ Colorado, Dept Phys Med & Rehabil, Anschutz Med Campus, Aurora, CO USA
[3] Univ Colorado, Dept Psychiat & Neurol, Anschutz Med Campus, Aurora, CO USA
[4] Mil & Vet Microbiome Consortium Res & Educ MVM Co, Denver, CO USA
[5] Univ Colorado, Dept Psychol & Neurosci, Boulder, CO 80309 USA
[6] Univ Colorado, Ctr Neurosci, Anschutz Med Campus, Aurora, CO USA
[7] Univ Colorado, Dept Integrat Physiol, Boulder, CO 80309 USA
[8] Univ Colorado, Ctr Neurosci, Boulder, CO 80309 USA
关键词
Bifidobacteria; Lactobacilli; Persistent post-concussive symptoms; Posttraumatic stress disorder; Prebiotic; Probiotic; PTSD; Synbiotic; TBI; Traumatic brain injury; Systematic review; LACTOBACILLUS-HELVETICUS R0052; BIFIDOBACTERIUM-LONGUM R0175; ANXIETY-LIKE BEHAVIOR; IN-VITRO; MODULATION; MEDICINE; PTSD; COMPLEMENTARY; RESILIENCE; SOLDIERS;
D O I
10.1016/j.bbi.2017.06.003
中图分类号
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号
071005 [微生物学]; 100108 [医学免疫学];
摘要
Traumatic brain injury (TBI) is highly prevalent among a wide range of populations, including civilians, military personnel, and Veterans. TBI sequelae may be further exacerbated by symptoms associated with frequently occurring comorbid psychiatric conditions, including posttraumatic stress disorder (PTSD). This is particularly true among the population of military personnel from recent conflicts in Iraq and Afghanistan, with a history of mild TBI (mTBI) and PTSD. The need for efficacious treatments for TBI and comorbid PTSD is significant, and evidence-based interventions for these frequently co-occurring conditions are limited. Based on findings suggesting that inflammation may be an underlying mechanism of both conditions, anti-inflammatory/immunoregulatory agents, including probiotics, may represent a novel strategy to treat TBI and/or PTSD-related symptoms. The focus of this systematic review was to identify and evaluate existing research regarding prebiotic and probiotic interventions for the populations of individuals with a history of TBI and/or PTSD. Only 4 studies were identified (3 severe TBI, 1 PTSD, 0 co-occurring TBI and PTSD). Although findings suggested some promise, work in this area is nascent and results to date do not support some claims within the extensive coverage of probiotics in the popular press. Published by Elsevier Inc.
引用
收藏
页码:57 / 67
页数:11
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