Genetic evidence that relative synaptic efficacy biases the outcome of synaptic competition

被引:242
作者
Buffelli, M
Burgess, RW
Feng, GP
Lobe, CG
Lichtman, JW
Sanes, JR
机构
[1] Washington Univ, Sch Med, Dept Anat & Neurobiol, St Louis, MO 63110 USA
[2] Univ Verona, Dipartimento Sci Neurol & Vis, I-37129 Verona, Italy
[3] Sunnybrook & Womens Coll Hlth Sci Ctr, Toronto, ON MN4 3M5, Canada
基金
美国国家卫生研究院;
关键词
D O I
10.1038/nature01844
中图分类号
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号
07 ; 0710 ; 09 ;
摘要
Synaptic activity drives synaptic rearrangement in the vertebrate nervous system; indeed, this appears to be a main way in which experience shapes neural connectivity(1,2). One rearrangement that occurs in many parts of the nervous system during early postnatal life is a competitive process called 'synapse elimination'(3,4). At the neuromuscular junction, where synapse elimination has been analysed in detail, muscle fibres are initially innervated by multiple axons, then all but one are withdrawn and the 'winner' enlarges(4-6). In support of the idea that synapse elimination is activity dependent, it is slowed or speeded when total neuromuscular activity is decreased or increased, respectively(4,7-13). However, most hypotheses about synaptic rearrangement postulate that change depends less on total activity than on the relative activity of the competitors(1-4,13,14). Intuitively, it seems that the input best able to excite its postsynaptic target would be most likely to win the competition, but some theories and results make other predictions(14-18). Here we use a genetic method to selectively inhibit neurotransmission from one of two inputs to a single target cell. We show that more powerful inputs are strongly favoured competitors during synapse elimination.
引用
收藏
页码:430 / 434
页数:5
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