DNA methylation and systemic lupus erythematosus

被引:70
作者
Balada, Eva [1 ]
Ordi-Ros, Josep [1 ]
Vilardell-Tarres, Miquel [1 ]
机构
[1] Hosp Valle De Hebron, Vall Dhebron Res Inst, Res Unit Systemat Autoimmune Dis, Barcelona 11912908035, Spain
来源
AUTOIMMUNITY, PT D: AUTOIMMUNE DISEASE, ANNUS MIRABILIS | 2007年 / 1108卷
关键词
systemic lupus erythematosus; T cells; DNA methylation;
D O I
10.1196/annals.1422.015
中图分类号
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号
100102 ;
摘要
Several studies have indicated the importance of DNA bypomethylation in the etiology of systemic lupus erythematosus (SLE). Different enzymes linked to the DNA methylation process have been described. The identification of all these enzymes means that cells have the capacity to modify their methylation patterns. Therefore, to obtain a deeper understanding of the role this epigenetic mechanism may have on SLE, the enzymes involved in the DNA methylation mechanism must be thoughtfully analyzed. In fact, studies of enzymes (other than DNMT1) in this autoimmune disease are still lacking. We have recently investigated the simultaneous gene expression of DNMT1, DNMT3A, DNMT3B, MBD2, and MBD4 in SLE patients. Here we review some of the studies that focus on the relationship between DNA methylation and SLE as well as we report our recent findings in this field. We suggest some alternative hypothesis that could help to understand the causes of the global DNA hypomethylation observed in the CD4(+) T cells of these patients.
引用
收藏
页码:127 / 136
页数:10
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