Long-term intrathecal S(+)-ketamine in a patient with cancer-related neuropathic pain

被引：27

作者：

Benrath, J ^{[1
]}

Scharbert, G

Gustorff, B

Adams, HA

Kress, HG

机构：

[1] Med Univ Vienna, Dept Anaesthesiol & Intens Care B, Vienna, Austria

[2] Med Univ Hanover, Dept Anaesthesia & Intens Care, Hannover, Germany

来源：

BRITISH JOURNAL OF ANAESTHESIA | 2005年 / 95卷 / 02期

关键词：

anaesthetic administration; intrathecal; long-term; anaesthetics i.v; S(+)-ketamine; pain; cancer-related; neuropathic;

D O I：

10.1093/bja/aei158

中图分类号：

R614 [麻醉学];

学科分类号：

100217 ;

摘要：

Neuropathic pain sometimes needs invasive pain therapy. We present the case of a patient with cancer-related neuropathic pain untreatable with conventional pain therapy after tumour-embolization. The patient was treated successfully with intrathecal (i.t.) administration of S(+)-ketamine, in addition to morphine. Plasma concentrations of S(+)-ketamine were measured regularly throughout the treatment. Continuous i.t. administration of S(+)-ketamine over a period of 3 months demonstrated low plasma levels and no unwanted side-effects.

引用

页码：247 / 249

页数：3

共 18 条

[1]

ADAMS HA, 1992, ANAESTHESIST, V41, P619

[2] INTRATHECAL KETAMINE FOR WAR SURGERY - A PRELIMINARY-STUDY UNDER FIELD CONDITIONS [J].

BION, JF .

ANAESTHESIA, 1984, 39 (10) :1023-1028

[3] Neural toxicity of ketamine and other NMDA antagonists [J].

de Lima, J ;

Beggs, S ;

Howard, R .

PAIN, 2000, 88 (03) :311-312

[4] SPINAL-CORD PHARMACOLOGY OF PAIN [J].

DICKENSON, AH .

BRITISH JOURNAL OF ANAESTHESIA, 1995, 75 (02) :193-200

[5] Ketamine in chronic pain management: An evidence-based review [J].

Hocking, G ;

Cousins, MJ .

ANESTHESIA AND ANALGESIA, 2003, 97 (06) :1730-1739

[6] Epidural ketamine potentiates epidural morphine but not fentanyl in acute nociception in rats [J].

Hoffmann, VLH ;

Baker, AK ;

Vercauteren, MP ;

Adriaensen, HF ;

Meert, TF .

EUROPEAN JOURNAL OF PAIN, 2003, 7 (02) :121-130

[7] The effects of ketamine and its enantiomers on the morphine- or dexmedetomidine-induced antinociception after intrathecal administration in rats [J].

Joó, G ;

Horvath, G ;

Klimscha, W ;

Kekesi, G ;

Dobos, I ;

Szikszay, M ;

Benedek, G .

ANESTHESIOLOGY, 2000, 93 (01) :231-241

[8] Cold allodynia and hyperalgesia in neuropathic pain:: the effect of N-methyl-D-aspartate (NMDA) receptor antagonist ketamine -: a double-blind, cross-over comparison with alfentanil and placebo [J].

Jorum, E ;

Warncke, T ;

Stubhaug, A .

PAIN, 2003, 101 (03) :229-235

[9] Subpial vacuolar myelopathy after intrathecal ketamine: report of a case [J].

Karpinski, N ;

Dunn, J ;

Hansen, L ;

Masliah, E .

PAIN, 1997, 73 (01) :103-105

[10] Long-term treatment with ketamine in a 12-year-old girl with severe neuropathic pain caused by a cervical spinal tumor [J].

Klepstad, P ;

Borchgrevink, P ;

Hval, B ;

Flaat, S ;

Kaasa, S .

JOURNAL OF PEDIATRIC HEMATOLOGY ONCOLOGY, 2001, 23 (09) :616-619

← 1 2 →