ABC transporters in Leishmania and their role in drug resistance

被引：59

作者：

Ouellette, M

Legare, D

Haimeur, A

Grondin, K

Roy, G

Brochu, C

Papadopoulou, B

机构：

[1] CHU Laval, Ctr Rech, Ctr Rech Infectiol, Ste Foy, PQ G1V 4G2, Canada

[2] Univ Laval, Fac Med, Div Microbiol, Quebec City, PQ G1K 7P4, Canada

来源：

DRUG RESISTANCE UPDATES | 1998年 / 1卷 / 01期

基金：

英国医学研究理事会;

关键词：

D O I：

10.1016/S1368-7646(98)80213-6

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

ABC transporters have been found in several parasitic protozoa including Leishmania. At least two Leishmania ABC transporters are involved in drug resistance. One is PgpA, which is involved in resistance to arsenic and antimony-containing compounds. Antimonials are the drug of choice against Leishmania infections. Transfection and biochemical studies suggest that PgpA recognizes metals conjugated to thiols. the second ABC transporter is closely related to mammalian P-glycoproteins and confers resistance to anticancer drugs by a mechanism that remains to be elucidated. Additional ABC transporters are likely to be present in Leishmania and these are discussed in relation to the phenomenon of antimony resistance.

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收藏

页码：43 / 48

页数：6

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